1404559-95-0Relevant articles and documents
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors
Wagner, Florence F.,We?wer, Michel,Steinbacher, Stefan,Schomburg, Adrian,Reinemer, Peter,Gale, Jennifer P.,Campbell, Arthur J.,Fisher, Stewart L.,Zhao, Wen-Ning,Reis, Surya A.,Hennig, Krista M.,Thomas, Méryl,Müller, Peter,Jefson, Martin R.,Fass, Daniel M.,Haggarty, Stephen J.,Zhang, Yan-Ling,Holson, Edward B.
supporting information, p. 4008 - 4015 (2016/08/23)
The structure–activity and structure–kinetic relationships of a series of novel and selective ortho-aminoanilide inhibitors of histone deacetylases (HDACs) 1 and 2 are described. Different kinetic and thermodynamic selectivity profiles were obtained by va