1404580-93-3Relevant academic research and scientific papers
Direct conversion of indoles to 3,3-difluoro-2-oxindoles via electrophilic fluorination
Lim, Yee Hwee,Ong, Qunxiang,Duong, Hung A.,Nguyen, Tuan Minh,Johannes, Charles W.
supporting information, p. 5676 - 5679 (2013/01/15)
3,3-Difluoro-2-oxindoles can be obtained directly from indoles in moderate yields via electrophilic fluorination using N-fluorobenzenesulfonimide as a mild fluorinating reagent. The presence of tert-butyl hydroperoxide during the reaction, together with additional heating after quenching the reaction with triethylamine, is beneficial to the formation of the desired product.
