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Amphotericin A is a polyene macrolide antibiotic derived from Streptomyces bacteria, structurally related to the well-known antifungal drug amphotericin B. It demonstrates broad-spectrum antifungal activity against a variety of fungal infections by binding to ergosterol in fungal cell membranes, disrupting cell integrity, and causing cell death. Despite its high toxicity and the existence of safer alternatives, it remains a significant interest in the development of new antifungal drugs.

1405-32-9

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1405-32-9 Usage

Uses

Used in Pharmaceutical Industry:
Amphotericin A is used as a research compound for the development of new antifungal drugs due to its broad-spectrum antifungal activity and unique mechanism of action.
Used in Clinical Practice:
Although not commonly used due to its high toxicity, amphotericin A is used as a last-resort treatment for severe fungal infections that are resistant to other antifungal agents, particularly in immunocompromised patients.
Used in Drug Delivery Systems:
Research is ongoing to develop novel drug delivery systems for amphotericin A to improve its safety profile, bioavailability, and therapeutic outcomes by encapsulating the drug in various carriers, such as liposomes or nanoparticles, to reduce its toxicity and enhance its efficacy against fungal infections.

Check Digit Verification of cas no

The CAS Registry Mumber 1405-32-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,0 and 5 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1405-32:
(6*1)+(5*4)+(4*0)+(3*5)+(2*3)+(1*2)=49
49 % 10 = 9
So 1405-32-9 is a valid CAS Registry Number.
InChI:InChI=1/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8-,13-11-,14-12+,17-15+,18-16+

1405-32-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (4E,6E,8E,10E,14E,16E)-3-(4-amino-3,5-dihydroxy-6-methyloxan-2-yl)oxy-19,25,27,30,31,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,14,16-hexaene-38-carboxylic acid

1.2 Other means of identification

Product number -
Other names Amphotericin A

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1405-32-9 SDS

1405-32-9Upstream product

1405-32-9Downstream Products

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