1405-46-5

Basic information

• Product Name: {(3R,5S)-5-[(3-acetylphenyl)amino]-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl}methyl 2-hydroxy-6-methylbenzoate
• CAS NO: 1405-46-5
• Molecular Formula: C₂₈H₃₈N₄O₈
• Molecular Weight: 558.6233
• Mol File: 1405-46-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 784.2°C at 760 mmHg
• Flash Point: 428.1°C
• Density: 1.38g/cm³
• Vapor Pressure: 6.66E-26mmHg at 25°C
• Refractive Index: 1.645
• CAS DataBase Reference: {(3R,5S)-5-[(3-acetylphenyl)amino]-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl}methyl 2-hydroxy-6-methylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: {(3R,5S)-5-[(3-acetylphenyl)amino]-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl}methyl 2-hydroxy-6-methylbenzoate(1405-46-5)
• EPA Substance Registry System: {(3R,5S)-5-[(3-acetylphenyl)amino]-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl}methyl 2-hydroxy-6-methylbenzoate(1405-46-5)

Safety Data

• Hazardous Substances Data: 1405-46-5(Hazardous Substances Data)

Usage

General Description

The chemical compound {(3R,5S)-5-[(3-acetylphenyl)amino]-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl}methyl 2-hydroxy-6-methylbenzoate is a complex molecule with multiple functional groups. It contains an acetylphenyl group, a dimethylcarbamoyl group, a hydroxyethyl group, and a benzoate group. The compound also features amino and hydroxyl groups, as well as a cyclopentyl ring. {(3R,5S)-5-[(3-acetylphenyl)amino]-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl}methyl 2-hydroxy-6-methylbenzoate has potential applications in pharmaceuticals, due to its diverse functional groups and complex structure, which could potentially contribute to its biological activity.

Upstream product

• 123-54-6 acetylacetone 
• 1449329-24-1 benzyl ((1S,2R,3R,4S,5S)-5-((3-acetylphenyl)amino)-2-(3,3-dimethylureido)-3,4-dihydroxy-2-((S)-1-hydroxyethyl)-4-(hydroxymethyl)-3-methylcyclopentyl)carbamate 
• 438187-09-8 2-hydroxy-6-methyl-benzoic acid cyanomethyl ester 
• 29397-21-5 Diacetyldiazomethan 
• 99-03-6 1-(3-aminophenyl)ethanone 
• 1449329-20-7 benzyl ((1R,2R,3R,5R)-3-((S)-1-((tert-butyldimethylsilyl)oxy)ethyl)-3-(3,3-dimethylureido)-5-(hydroxymethyl)-4-oxo-6-oxabicyclo[3.1.0]hexan-2-yl)carbamate 
• 1449329-18-3 C₂₅H₄₁N₃O₇Si 
• 1449329-12-7 3-(2,4-dioxopentan-3-yl)-1,1-dimethylurea 
• 1449329-25-2 ((1S,2R,3R,4S,5S)-5-((3-acetylphenyl)amino)-4-(((benzyloxy)carbonyl)amino)-3-(3,3-dimethylureido)-1,2-dihydroxy-3-((S)-1-hydroxyethyl)-2-methylcyclopentyl)methyl 2-hydroxy-6-methylbenzoate 
• 1449329-23-0 benzyl ((1S,2R,3R,4S,5S)-5-((3-acetylphenyl)amino)-2-((S)-1-((tert-butyldimethylsilyl)oxy)ethyl)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(3,3 dimethylureido)-3,4-dihydroxy-3-methylcyclopentyl)carbamate 
• 1449329-22-9 benzyl ((1R,2R,3R,4R,5R)-3-((S)-1-((tert-butyldimethylsilyl)oxy)ethyl)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-(3,3-dimethylureido)-4-hydroxy-4-methyl-6-oxabicyclo[3.1.0]hexan-2-yl)carbamate 
• 1449329-21-8 benzyl ((1R,2R,3R,5R)-3-((S)-1-((tert-butyldimethylsilyl)oxy)ethyl)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-(3,3-dimethylureido)-4-oxo-6-oxabicyclo[3.1.0] hexan2-yl)carbamate 

Downstream Products

• 69313-72-0 Pactamycin-Aceton-Addukt 

Relevant articles and documents

SYNTHETIC ROUTE TO PACTAMYCIN AND PACTAMYCIN ANALOGS

Methods and intermediates useful for making compounds of Formula (I) are described, including a general method of making an alpha, beta-diamino ketone by reacting an imine with a 2-amino-substituted 1,3-dicarbonyl in a Mannich addition reaction to produce said alpha,beta-diamino ketone.

Asymmetric synthesis of the aminocyclitol pactamycin, a universal translocation inhibitor

An asymmetric total synthesis of the aminocyclopentitol pactamycin is described. The title compound is delivered in 15 steps from 2,4-pentanedione. Critical to this approach was the exploitation of a complex symmetry-breaking reduction strategy to assemble the C1, C2, and C7 relative stereochemistry within the first four steps of the synthesis. Multiple iterations of this reduction strategy are described, and a thorough analysis of stereochemical outcomes is detailed. In the final case, an asymmetric Mannich reaction was developed to install a protected amine directly at the C2 position. Symmetry-breaking reduction of this material gave way to a remarkable series of stereochemical outcomes leading to the title compound without recourse to nonstrategic downstream manipulations. This synthesis is immediately accommodating to the preparation of structural analogs.