1405680-11-6Relevant articles and documents
Rapid synthesis of substituted pyrrolines and pyrrolidines by nucleophilic ring closure at activated oximes
Chandan, Nandkishor,Thompson, Amber L.,Moloney, Mark G.
supporting information, p. 7863 - 7868 (2013/07/05)
Substituted pyrrolines are available by ring closure initiated by direct nucleophilic attack of stabilized enolates at the nitrogen of oximes activated with a leaving group, in a process which effectively out-competes the more usual Beckmann rearrangement. Subsequent reduction provides diastereoselective access to the corresponding pyrrolidines. This provides a rapid route to saturated heterocyclic systems from readily available precursors.
