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1406-11-7

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1406-11-7 Usage

Chemical Properties

All are basic polypeptides. Soluble in water; the hydrochlorides are soluble in water and methanol, insoluble in ether, acetone, chlorinated solvents, and hydrocarbons. Permissible food additives.

Originator

Aerosporin, Burroughs-Wellcome, US,1951

Uses

Medicine (antibiotic), beer production.

Definition

Generic term for a series of antibiotic substances produced by strains of Bacillus polymyxa. Various polymyxins are differentiated by the letters A, B, C, D, and E. All are active against certain gram-negative bacteria. Polymyxin B is most used.

Manufacturing Process

As described in US Patent 2,595,605, in a pilot plant tank 225 liters of a medium containing the following ingredients was prepared: 2% ammonium sulfate, 0.2% potassium dihydrogen phosphate, 0.05% magnesium sulfateheptahydrate, 0.005% sodium chloride, 0.001% ferrous sulfate heptahydrate, 0.5% yeast extract, 1% dextrose, 1% calcium carbonate and 3% corn meal. The fermentation medium was adjusted to pH 7.3 to 7.4. It was then sterilized for 30 minutes at 110°C. After sterilization the pH was about 7. To the medium was added 225 ml of mineral oil.The fermentation medium was inoculated with Bacillus polymyxa prepared as follows: A culture of Bacillus polymyxa in a tube with Trypticase soybean broth was incubated overnight at 25°C. 5 ml of this culture was transferred to 100 ml of the tank medium in a 500 ml Erlenmeyer flask which was incubated for 48 hours at room temperature. This 100 ml culture served as inoculum for one tank. During the course of fermentation the medium was aerated at the rate of 0.3 volume of air per volume of mash per minute. The temperature was maintained at about 27°C. Samples of mash were taken every 8 hours in order to determine pH and the presence of contaminants and spores. After 88 hours of fermentation the pH was about 6.3 and an assay using Escherichia coli showed the presence of 1,200 units of polymyxin per cubic centimeter. The polymyxin was extracted and purified by removing the mycelia, adsorbing the active principle on charcoal and eluting with acidic methanol.Polymyxin is usually used as the sulfate.

Therapeutic Function

Antibacterial

Contact allergens

Polymyxin, CAS Registry Number, is a polypeptidic antibiotic complex (Polymyxin A to E) produced by Bacillus polymyxa. Polymyxin E is known as Colistin.

Safety Profile

Poison by intraperitoneal, subcutaneous, and intravenous routes. An adQtive permitted in food for human consumption.

Check Digit Verification of cas no

The CAS Registry Mumber 1406-11-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,0 and 6 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1406-11:
(6*1)+(5*4)+(4*0)+(3*6)+(2*1)+(1*1)=47
47 % 10 = 7
So 1406-11-7 is a valid CAS Registry Number.
InChI:InChI=1/C48H82N16O14/c1-24(2)22-34-44(73)57-28(10-16-49)38(67)56-31(13-19-52)42(71)63-36(25(3)65)46(75)54-21-15-33(41(70)55-29(11-17-50)40(69)61-35(45(74)60-34)23-27-8-6-5-7-9-27)58-39(68)30(12-18-51)59-47(76)37(26(4)66)64-43(72)32(14-20-53)62-48(77)78/h5-9,24-26,28-37,62,65-66H,10-23,49-53H2,1-4H3,(H,54,75)(H,55,70)(H,56,67)(H,57,73)(H,58,68)(H,59,76)(H,60,74)(H,61,69)(H,63,71)(H,64,72)(H,77,78)/t25-,26-,28+,29+,30+,31+,32+,33+,34+,35-,36+,37+/m1/s1

1406-11-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name [(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3

1.2 Other means of identification

Product number -
Other names Polymyxinum

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1406-11-7 SDS

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