1406-72-0
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Basic information
- Product Name: RESTRICTOCIN
- Synonyms: RESTRICTOCIN;nsc-53398;restrictocin from aspergillus*restrictus
- CAS NO:1406-72-0
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: 3.x.x.x Hydrolases;Enzyme Class Index;Others
- Mol File: 1406-72-0.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −20°C
- Solubility: N/A
- CAS DataBase Reference: RESTRICTOCIN(CAS DataBase Reference)
- NIST Chemistry Reference: RESTRICTOCIN(1406-72-0)
- EPA Substance Registry System: RESTRICTOCIN(1406-72-0)
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Safety Data
- Hazard Codes: Xn
- Statements: 20/21/22-42/43
- Safety Statements: 26-36
- WGK Germany: 3
- RTECS: VH4725000
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1406-72-0(Hazardous Substances Data)
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General Description
Restrictocin is a small, highly toxic protein that acts as a ribonuclease, specifically cleaving the 28S rRNA of the eukaryotic ribosome. It is produced by the fungus Aspergillus restrictus and has been studied for its potential use as an anticancer agent due to its ability to selectively target and kill cancer cells. Restrictocin has also been investigated for its potential use in biotechnology, as it can be genetically modified to specifically target and destroy cells expressing a certain protein. However, due to its toxicity, careful consideration and further research is needed to fully understand its potential therapeutic applications.Check Digit Verification of cas no
The CAS Registry Mumber 1406-72-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,0 and 6 respectively; the second part has 2 digits, 7 and 2 respectively.Calculate Digit Verification of CAS Registry Number 1406-72:
(6*1)+(5*4)+(4*0)+(3*6)+(2*7)+(1*2)=60
60 % 10 = 0
So 1406-72-0 is a valid CAS Registry Number.
1406-72-0Upstream product
1406-72-0Downstream Products
1406-72-0Related news
The cDNA clone of restrictocin was placed under the control of the glucoamylase promoter from Aspergillus awamori and was transformed into Aspergillus nidulans and Aspergillus niger. Site-specific changes were introduced into cDNA constructs and these were transformed into A. nidulans. The secre...detailed
Restrictocin is a toxin produced by the fungus Aspergillus restrictus. The DNA coding for restrictocin was isolated from the host by polymerase chain reaction and cloned into a T7 promoter-based expression vector. The protein was overproduced in Escherichia coli and remained insoluble in the cel...detailed
Restrictocin, a highly specific ribonuclease produced by Aspergillus restrictus, cleaves a single phosphodiester bond in a universally conserved stem and loop structure termed sarcin/ricin loop within the large ribosomal RNA of all organisms. In the current study, we demonstrate restrictocin to ...detailed
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