140605-82-9

Upstream product

• 2579-22-8 Phenylpropargyl aldehyde 
• 18292-38-1 2-methallyltrimethylsilane 
• 57187-82-3 (3-((2-methylallyl)oxy)prop-1-yn-1-yl)benzene 
• 5674-01-1 2-methylallylmagnesium chloride 
• 563-47-3 3-Chloro-2-methylpropene 

Downstream Products

• 1353572-27-6 C₁₉H₂₈OSi 
• 1353572-24-3 5-methyl-1-phenylbicyclo[3.1.0]hexan-3-one 
• 1353572-19-6 C₂₃H₂₆O₄ 
• 1353572-20-9 C₂₃H₂₆O₄ 
• 130747-81-8 cis-2-(Hydroxymethyl)-5-methyl-3-phenyl-2-cyclohexenol 
• 130747-79-4 2-(Hydroxymethyl)-4,4-dimethyl-3-phenyl-2-cyclopentenol 

Relevant academic research and scientific papers

Gold-catalyzed synthesis of 1,3-disubstituted benzenes through tandem allylation/cyclization reaction of alkynals

Treatment of alkynals with 2-substituted allylsilanes and PPh3AuCl/AgOTf (5/3 mol%) catalyst led to formation of 1,3-disubstituted benzenes efficiently. This reaction sequence comprises an initial allylation of aldehyde, followed by cycloisomerization of enynes; PPh3AuOTf is active in both steps.

Synthesis, Characterization, and Catalytic Activity of Chiral NHC Platinum(II) Pyridine Dihalide Complexes

A series of platinum(II) dihalide pyridine complexes bearing chiral C2-symmetric N-heterocyclic carbene (NHC) ligands [Pt(NHC*)(Py)(Hal)2] was synthesized in a one-pot procedure and characterized by NMR spectroscopy and single crystal X-ray diffraction (SC-XRD). The complexes were tested for the asymmetric cycloisomerization of enynol into bicyclo[3.1.0]hexanone and feature an excellent catalytic activity at room temperature along with a modest enantiomeric induction (up to 39% ee).

De Novo Synthesis of Highly Functionalized Benzimidazolones and Benzoxazolones through an Electrochemical Dehydrogenative Cyclization Cascade

Benzimidazolone and benzoxazolone moieties are important scaffolds in a variety of pharmaceutical molecules. These bicyclic heterocycles are usually prepared from a benzene derivative through the construction of an additional five-membered heterocyclic ri

Radical Cyclization of (Bromomethyl)dimethylsilyl Propargyl Ethers. Regio-, Chemo-, and Stereoselectivity

Radical cyclization of (bromomethyl)dimethylsilyl propargyl ether derivatives 1 is a powerful reaction with a high degree of regio-, chemo-, and stereoselectivity.Trisubstituted olefins 3, cyclopentene derivatives 5, and diquinane system 7j are obtained in good yields by a judicious choice of unsaturated substituents.Triquinane frameworks could be obtained stereoselectively from a suitable acyclic substrate of type 1 in a one-pot reaction.First attempts have not yet allowed us to aim at this goal due to interesting (1,5) hydrogen transfers.Moreover, we have intercepted, for the first time, the α-cyclopropyl radical which is involved in the Storck-Beckwith mechanism of the 5-versus 6-membered ring formation in the vinyl radical cyclization.