140608-64-6

Basic information

• Product Name: Muromonab-CD3
• Synonyms: Muromonab-CD3
• CAS NO: 140608-64-6
• Mol File: 140608-64-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Muromonab-CD3(CAS DataBase Reference)
• NIST Chemistry Reference: Muromonab-CD3(140608-64-6)
• EPA Substance Registry System: Muromonab-CD3(140608-64-6)

Safety Data

• Hazardous Substances Data: 140608-64-6(Hazardous Substances Data)

Usage

Description

Muromonab-CD3, also known as Orthoclone-OKT3, is a murine monoclonal antibody that targets the T3 antigen of human T-cells, effectively blocking their killing ability. It is an unmodified mouse immunoglobulin, classified as an IgG2a, and plays a crucial role in the treatment of acute allograft rejection in organ transplant recipients.

Uses

Used in Pharmaceutical Industry:
Muromonab-CD3 is used as an immunosuppressant for the treatment of acute allograft rejection in heart and liver transplant recipients who are resistant to standard steroid therapies. By binding to the CD3 glycoprotein on the surface of mature T lymphocytes, it prevents signal transduction into T cells, thereby blocking the function of T cells involved in acute renal rejection.
Used in Transplant Medicine:
Muromonab-CD3 is used as a therapeutic agent in renal transplant patients to treat acute allograft rejection. Its ability to block T-cell activity helps in preventing the immune system from attacking the transplanted organ, thus improving the success rate of the transplant procedure.
Brand Name:
Orthoclone (Ortho Pharmaceutical); OKT3 (Ortho Pharmaceutical); ORTHOCLONE OKT3.

Originator

Ortho (USA)

Mechanism of action

Muromonab-(CD3) alters the cell-mediated immune response by binding to the CD3 (cluster of differentiation antigen, T3) glycoprotein on T lymphocytes. This binding inhibits lymphocyte activation so that affected T cells cannot recognize foreign antigen and cannot participate in rejecting an organ graft.Within minutes of the first muromonab-(CD3) injection, total circulating T cells are rapidly depleted from the blood. They later reappear devoid of CD3 and antigen recognition complexes.

Clinical Use

Muromonab-(CD3) (Orthoclone OKT3) is a mouse monoclonal antibody that is a purified IgG. It is used for the prevention of acute allograft rejection in kidney and hepatic transplants and as prophylaxis in cardiac transplantation. It is also used to deplete T cells in marrow from donors before bone marrow transplantation.

Side effects

Adverse side effects include fever, pulmonary edema, vomiting, headache, and anaphylaxis. Neutralizing antibodies may develop over time and necessitate adjusting the dosage upward to compensate for the loss of therapeutic activity.