140608-64-6 Usage
Description
Muromonab-CD3, also known as Orthoclone-OKT3, is a murine monoclonal antibody that targets the T3 antigen of human T-cells, effectively blocking their killing ability. It is an unmodified mouse immunoglobulin, classified as an IgG2a, and plays a crucial role in the treatment of acute allograft rejection in organ transplant recipients.
Uses
Used in Pharmaceutical Industry:
Muromonab-CD3 is used as an immunosuppressant for the treatment of acute allograft rejection in heart and liver transplant recipients who are resistant to standard steroid therapies. By binding to the CD3 glycoprotein on the surface of mature T lymphocytes, it prevents signal transduction into T cells, thereby blocking the function of T cells involved in acute renal rejection.
Used in Transplant Medicine:
Muromonab-CD3 is used as a therapeutic agent in renal transplant patients to treat acute allograft rejection. Its ability to block T-cell activity helps in preventing the immune system from attacking the transplanted organ, thus improving the success rate of the transplant procedure.
Brand Name:
Orthoclone (Ortho Pharmaceutical); OKT3 (Ortho Pharmaceutical); ORTHOCLONE OKT3.
Originator
Ortho (USA)
Mechanism of action
Muromonab-(CD3) alters the cell-mediated immune
response by binding to the CD3 (cluster of differentiation
antigen, T3) glycoprotein on T lymphocytes.
This binding inhibits lymphocyte activation so that affected
T cells cannot recognize foreign antigen and cannot
participate in rejecting an organ graft.Within minutes
of the first muromonab-(CD3) injection, total
circulating T cells are rapidly depleted from the blood.
They later reappear devoid of CD3 and antigen recognition
complexes.
Clinical Use
Muromonab-(CD3) (Orthoclone OKT3) is a mouse
monoclonal antibody that is a purified IgG. It is used
for the prevention of acute allograft rejection in kidney
and hepatic transplants and as prophylaxis in cardiac
transplantation. It is also used to deplete T cells in
marrow from donors before bone marrow transplantation.
Side effects
Adverse side effects include fever, pulmonary
edema, vomiting, headache, and anaphylaxis. Neutralizing
antibodies may develop over time and necessitate
adjusting the dosage upward to compensate for the loss
of therapeutic activity.
Check Digit Verification of cas no
The CAS Registry Mumber 140608-64-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,0,6,0 and 8 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 140608-64:
(8*1)+(7*4)+(6*0)+(5*6)+(4*0)+(3*8)+(2*6)+(1*4)=106
106 % 10 = 6
So 140608-64-6 is a valid CAS Registry Number.