14062-34-1

Basic information

• Product Name: 3-AMINOBENZHYDRAZIDE
• Synonyms: 3-Aminobenzohydrazide;Benzoic acid, 3-amino-, hydrazide;LABOTEST-BB LT00453555;M-AMINOBENZHYDRAZIDE;3-AMINOBENZHYDRAZIDE;m-aminobenzohydrazide;3-Aminobenzhydrazide, 98+%;Benzoic acid, 3-amino-, hydrazide (9CI)
• CAS NO: 14062-34-1
• Molecular Formula: C₇H₉N₃O
• Molecular Weight: 151.17
• EINECS: 237-907-8
• Product Categories: AMIDE;Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 14062-34-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 91-92°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.267g/cm³
• Refractive Index: 1.641
• PKA: 12.48±0.10(Predicted)
• BRN: 2090097
• CAS DataBase Reference: 3-AMINOBENZHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINOBENZHYDRAZIDE(14062-34-1)
• EPA Substance Registry System: 3-AMINOBENZHYDRAZIDE(14062-34-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 14062-34-1(Hazardous Substances Data)

Usage

General Description

3-Aminobenzhydrazide is an organic compound with the chemical formula C7H9N3O. It is a white to off-white powder that is used in the production of azo dyes. 3-Aminobenzhydrazide is also used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a water-soluble compound that is stable under normal conditions, but may decompose if heated to high temperatures. The compound has potential applications in the field of medicine, agriculture, and industry due to its versatile chemical properties and reactivity.

InChI:InChI=1/C7H9N3O/c8-6-3-1-2-5(4-6)7(11)10-9/h1-4H,8-9H2,(H,10,11)

Upstream product

• 99-05-8 meta-aminobenzoic acid 
• 4518-10-9 Methyl 3-aminobenzoate 
• 582-33-2 3-aminobenzoic acid ethyl ester 

Downstream Products

• 115082-05-8 5-(3-amino-phenyl)-3H-[1,3,4]oxadiazol-2-one 
• 107922-59-8 3-amino-benzoic acid benzylidenehydrazide 
• 1709-44-0 m-aminobenzaldehyde 
• 146055-58-5 {manganese(II) bis(m-aminobenzoic hydrazide)Cl₂} 
• 203268-82-0 5-(3-aminophenyl)-1,3,4-oxadiazole-2-thiol 
• 1430092-78-6 C₁₄H₁₁N₃O₂S 
• 807628-53-1 C₃₁H₃₄N₆O₅Si 

Relevant articles and documents

Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction

Defective in cullin neddylation 1(DCN1) is a co-E3 ligase that is important for cullin neddylation. Dysregulation of DCN1 highly correlates with the development of various cancers. Herein, from the initial high-throughput screening, a novel hit compound 5a containing a phenyltriazole thiol core (IC50 value of 0.95 μM for DCN1-UBC12 interaction) was discovered. Further structure-based optimization leads to the development of SK-464 (IC50 value of 26 nM). We found that SK-464 not only directly bound to DCN1 in vitro, but also engaged cellular DCN1, suppressed the neddylation of cullin3, and hindered the migration and invasion of two DCN1-overexpressed squamous carcinoma cell lines (KYSE70 and H2170). These findings indicate that SK-464 may be a novel lead compound targeting DCN1-UBC12 interaction.

ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF

The present disclosure relates to a compound as shown in formula (II), a tautomer or a pharmaceutically acceptable salt thereof, and disclosed is the use thereof in preparing a drug for treating an ASK1-associated disease.

Tyrosinase and carbonic anhydrase enzymes inhibition studies of vanadium(V) complexes

Present study endeavors synthesis of series of vanadium(V) hydrazide complexes and its enzyme inhibition studies. Octahedral structure of complexes has been evaluated previously using conductance measurements, spectroscopic techniques involving IR,1H-NMR and13C-NMR, elemental analysis using CHN technique. Complexes 1c-12c have found to exhibit monomeric form with hydrazides behaving as bidentate ligand coordinating by their N and O atoms, while two oxygen atoms have also been found to show attachment with the metal centre. This study includes activity of vanadium(V) complexes to inhibit tyrosinase and carbonic anhydrase enzymes. For inhibition of carbonic anhydrase all, while for tyrosinase most of the hydrazide ligands were found to be inactive. Vanadium(V) complexes with these hydrazides have found to bear variable degree of carbonic anhydrase and tyrosinase inhibition activity. Some of the vanadium(V) hydrazide complexes were found to be potent inhibitors of tyrosinase enzyme and carbonic anhydrase as well.