140623-93-4 Usage
Synthetic molecule
It is a man-made compound, not found naturally in living organisms.
Derivative of D-arabinitol
It is derived from the sugar D-arabinitol, which is a pentitol (five-carbon sugar alcohol).
Contains a thymine base
The molecule has a thymine base attached to it, which is one of the four nucleobases in DNA.
Nucleoside analog
It is structurally similar to a natural nucleoside but with some modifications, making it an analog.
Antiviral and antitumor potential
It has been studied for its potential use in treating viral infections and cancer.
Inhibition of DNA and RNA synthesis
The molecule is designed to interfere with the replication of viral and tumor cells by inhibiting their DNA and RNA synthesis.
Activity against herpes simplex virus
Research has shown that it exhibits promising antiviral activity against herpes simplex virus (HSV).
Activity against cytomegalovirus
It also shows potential in inhibiting the replication of cytomegalovirus (CMV).
Antitumor activity
The molecule has demonstrated antitumor activity against various cancer cell lines.
Unique structure
Its distinct chemical structure contributes to its potential therapeutic applications.
Further study and drug development
Due to its promising properties, it is an interesting candidate for further research in the development of new antiviral and antitumor drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 140623-93-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,0,6,2 and 3 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 140623-93:
(8*1)+(7*4)+(6*0)+(5*6)+(4*2)+(3*3)+(2*9)+(1*3)=104
104 % 10 = 4
So 140623-93-4 is a valid CAS Registry Number.
140623-93-4Relevant articles and documents
A new general synthesis of isomeric nucleosides
Bera, Sanjib,Nair, Vasu
, p. 5813 - 5815 (2007/10/03)
An efficient new method for the synthesis of isonucleosides is described. The key step in the synthesis was the direct coupling of purine and pyrimidine bases with the cyclic sulfate of a carbohydrate intermediate. This reaction proceeded with high regiospecificity and stereospecificity.
Synthesis of isonucleosides related to AZT and AZU
Purdy,Zintek,Nair
, p. 109 - 126 (2007/10/02)
Approaches to 1,4-anhydro-3-azido-2,3-dideoxy-2-[3,4-dihydro-2,4-dioxo-5- methyl-1(2H)-pyrimidinyl]-D-arabinitol, and the related uracil derivative, have been developed. These conceptually new, optically active analogs of AZT, derived from 1,4-anhydro-D-ribitol, are among the first examples of regioisomeric analogs of AZT.
SYNTHETIC APPROACHES TO NEW REGIOISOMERS OF AZT AND AZU
Nair, Vasu,Purdy, David F.
, p. 421 - 425 (2007/10/02)
Approaches to 1,4-anhydro-3-α-azido-2,3-dideoxy-2-β--D-arabinitol and 1,4-anhydro-3-α-azido-2,3-dideoxy-2-β--D-arabinitol, conceptually new hydrolytically stable, optically active analogs of 3'-α-azido-3'-deoxythymidine (AZT) have been developed.These are among the first examples of regioisomeric analogs of AZT.The key synthetic steps and key intermediates are described.The generality aspects of the approaches are addressed.