14063-78-6

Basic information

• Product Name: (2Z)-3-(4-bromophenyl)-3-chloroprop-2-enal
• Synonyms: 2-Propenal, 3-(4-bromophenyl)-3-chloro-;(2Z)-3-(4-bromophenyl)-3-chloroprop-2-enal
• CAS NO: 14063-78-6
• Molecular Formula: C₉H₆BrClO
• Molecular Weight: 245.5003
• EINECS: 630-796-0
• Mol File: 14063-78-6.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 328.2°C at 760 mmHg
• Flash Point: 152.3°C
• Density: 1.547g/cm³
• Vapor Pressure: 0.000192mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: (2Z)-3-(4-bromophenyl)-3-chloroprop-2-enal(CAS DataBase Reference)
• NIST Chemistry Reference: (2Z)-3-(4-bromophenyl)-3-chloroprop-2-enal(14063-78-6)
• EPA Substance Registry System: (2Z)-3-(4-bromophenyl)-3-chloroprop-2-enal(14063-78-6)

Safety Data

• Hazardous Substances Data: 14063-78-6(Hazardous Substances Data)

Upstream product

• 3724-43-4 Vilsmeier reagent 
• 99-90-1 para-bromoacetophenone 
• 68-12-2 N,N-dimethyl-formamide 
• 41876-64-6 2-chloro-2-(4-bromophenyl)ethene 
• 766-96-1 4-bromo-1-ethynylbenzene 

Downstream Products

• 766-96-1 4-bromo-1-ethynylbenzene 
• 78583-87-6 (E)-3-(4-Bromo-phenyl)-3-chloro-acrylonitrile 
• 936368-52-4 (Z)-3-(4-bromophenyl)-3-chloro-2-propenenitrile 
• 85093-02-3 2-(p-bromophenyl)-5-methylthiophene 

Relevant articles and documents

Ugi Reaction Followed by Intramolecular Diels–Alder Reaction and Elimination of HCl: One-Pot Approach to Arene-Fused Isoindolinones

A one-pot procedure involving a four-component Ugi reaction followed by an intramolecular Diels–Alder reaction/HCl elimination cascade has been developed to provide rapid access to the isoindolinone framework in a diversity-oriented fashion. The scope of

Superacid-promoted synthesis of quinoline derivatives

A series of vinylogous imines have been prepared from anilines and cinnamaldehydes. These substrates react in superacidic media to provide quinolines and related compounds. A mechanism for the conversion is proposed which involves the cyclization of dicationic superelectrophilic intermediates. Aromatization of the quinoline ring is thought to occur by superacid-promoted elimination of benzene.

Base-Promoted Intermolecular Cyclization of Substituted 3-Aryl(Heteroaryl)-3-chloroacrylaldehydes and Tetrahydroisoquinolines: An Approach to Access Pyrrolo[2,1-a]isoquinolines

We have developed a new base-promoted intermolecular cascade cyclization reaction of substituted 3-aryl(heteroaryl)-3-chloroacrylaldehydes and tetrahydroisoquinolines in one pot. The reaction provides a facile and practical synthesis of pyrrolo[2,1-a]isoquinolines. A number of pyrrolo[2,1-a]isoquinolines were synthesized in moderate to high yields (up to 97%).