140635-50-3Relevant academic research and scientific papers
CRYTOPORIC ACIDS A-G, DRIMANE-TYPE SESQUITERPENOID ETHERS OF ISOCITRIC ACID FROM THE FUNGUS CRYPTOPORUS VOLVATUS
Asakawa, Yoshinori,Hashimoto, Toshihiro,Mizuno, Yasuo,Tori, Motoo,Fukazawa, Yoshimasa
, p. 579 - 592 (1992)
Seven novel bitter drimane-type sesquiterpenoids with an isocitric acid group named cryptoporic acids (CA) A-G have been isolated from the fungus Cryptoporus volvatus and their absolute stereostructures established by a combination of chemical transformation, NMR spectral data and X-ray crystallographic analysis.Crytoporic acids strongly inhibited the release of superoxide anion radicals from guinea-pig peritoneal macrophage as well as rabbit polymorphonuclear leucocyte.CA-E showed anti-tumour promoting activity whilst CA-D slightly enhanced tumour promoting and protein kinase C activity.CAs also inhibited elongation of the second coleoptile and germination of rice in husk at 200 ppm. Key words: Cryptoporus volvatus; Polyporaceae; fungus; drimane-type sesquiterpenoid ethers; isocitric acid; superoxide anion radical release inhibitor; anti-tumour and tumour promoting activity; protein kinase C enhancement; plant growth inhibitory activity; bitter principles.
Biologically active substances of Japanese inedible mushrooms
Hashimoto, Toshihiro,Asakawa, Yoshinori
, p. 1067 - 1110 (2007/10/03)
As a part of our systematic investigation of biologically active substances of inedible mushrooms, we studied the chemical constituents of three Basidiomycetes fungi (Cryptoporus volvatus, Lentinellus ursinus and Paxillus atrotomentosus), five inedible Ascomycetes fungi (Daldinia concentrica, Daldinia vernicosa, Entonaema splendens, Hypoxylon truncatum and Ascoclavulina sakaii), and isolated a number of novel terpenoids, phenolics and nitrogen-containing compounds. The isolation, structural determination and biological activity of the new compounds will be discussed.
