140655-01-2Relevant academic research and scientific papers
Aqueous one-pot synthesis of pyrazoles, pyrimidines and isoxazoles promoted by microwave irradiation
Molteni, Valentina,Hamilton, Matthew M.,Mao, Long,Crane, Christine M.,Termin, Andreas P.,Wilson, Dean M.
, p. 1669 - 1674 (2007/10/03)
Microwave irradiation promotes the conversion of enaminoketones formed in situ into a variety of heterocycles by reaction with the appropriate bidentate nucleophile. The advantages of the method over previous approaches are short reaction times and facile purification by precipitation of the products in aqueous media. Moreover the convenient one-pot procedure makes these syntheses particularly suitable for library production. Organic reactions in aqueous media have become of great interest as water is not only more environmentally friendly, but also because organic reactions in water often display unique reactivity and selectivity.
Synthesis of 5-propynyloxycycloalkanepyrimidines and their selectivity and reactivity in intramolecular Diels-Alder reactions
Stolle, Werner A. W.,Veurink, Jacqueline M.,Marcelis, Antonius T. M.,Van Der Plas, Henk C.
, p. 1643 - 1656 (2007/10/02)
The 5-propynyloxycycloalkane pyrimidines IIIA (17-20), IIIB (21-24), and IIIC (25, 26) and the 5-(1-propynyloxyethyl) pyrimidines IIID (27,28), easily undergo intramolecular Diels-Alder reactions with inverse electron demand and a subsequent retro Diels-A
