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140669-75-6

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140669-75-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 140669-75-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,0,6,6 and 9 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 140669-75:
(8*1)+(7*4)+(6*0)+(5*6)+(4*6)+(3*9)+(2*7)+(1*5)=136
136 % 10 = 6
So 140669-75-6 is a valid CAS Registry Number.

140669-75-6Upstream product

140669-75-6Relevant articles and documents

Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases

Ekambaram, Ramesh,Enkvist, Erki,Manoharan, Ganesh Babu,Ugandi, Mihkel,Kasari, Marje,Viht, Kaido,Knapp, Stefan,Issinger, Olaf-Georg,Uri, Asko

, p. 4096 - 4098 (2014)

Benzoselenadiazole-containing inhibitors of protein kinases were constructed and their capability to emit phosphorescence in the kinase-bound state was established. Labelling of the inhibitors with a red fluorescent dye led to sensitive responsive photoluminescent probes for protein kinase CK2 that emitted red light with a long (microsecond-scale) decay time upon excitation of the probes with a pulse of near-UV light. This journal is the Partner Organisations 2014.

Microwave-Assisted Syntheses of Benzimidazole-Containing Selenadiazole Derivatives That Induce Cell-Cycle Arrest and Apoptosis in Human Breast Cancer Cells by Activation of the ROS/AKT Pathway

Liang, Yuanwei,Zhou, Yangliang,Deng, Shulin,Chen, Tianfeng

, p. 2339 - 2346 (2016)

The use of selenium-containing heterocyclic compounds as potent cancer chemopreventive and chemotherapeutic agents has been well documented by a large number of clinical studies. In this study we developed a new approach to synthesize four benzimidazole-containing selenadiazole derivatives (BSeDs). The method uses a combination of peptide coupling reagents and microwave irradiation. This strategy features milder reaction conditions, higher yields, and shorter reaction times. The synthetic BSeDs were identified as potent antiproliferative agents against the human MCF-7 and MDA-MB-231 breast cancer cell lines. Compounds 1 b (5-(6-methyl-1H-benzo[d]imidazol-2-yl)benzo[c][1,2,5]selenadiazole), 1 c (5-(6-chloro-1H-benzo[d]imidazol-2-yl)benzo[c][1,2,5]selenadiazole), and 1 d (5-(6-bromo-1H-benzo[d]imidazol-2-yl)benzo[c][1,2,5]selenadiazole) were found to show greater cytotoxicity against the triple-negative breast cancer cell line MDA-MB-231 than MCF-7, and to exhibit dose-dependent inhibition of cell migration, in which a significant decrease in the zone of cell monolayer wound closure was observed relative to untreated controls. Our results demonstrate that BSeDs can cause cell-cycle arrest and apoptosis in MDA-MB-231 cells by inducing DNA damage, inhibiting protein kinase B (AKT), and activating mitogen-activated protein kinase (MAPK) family members through the overproduction of reactive oxygen species (ROS). Taken together, the results of this study provide a facile microwave-assisted strategy for the synthesis of selenium-containing organic compounds that exhibit a high level of anticancer efficacy.

Substitution Effect on 2-(Oxazolinyl)-phenols and 1,2,5-Chalcogenadiazole -Annulated Derivatives: Emission-Color-Tunable, Minimalistic Excited-State Intramolecular Proton Transfer (ESIPT)-Based Luminophores

G?bel, Dominik,Rusch, Pascal,Duvinage, Daniel,Stauch, Tim,Bigall, Nadja-C.,Nachtsheim, Boris J.

supporting information, p. 14333 - 14355 (2021/10/20)

Minimalistic 2-(oxazolinyl)-phenols substituted with different electron-donating and -withdrawing groups as well as 1,2,5-chalcogenadiazole-annulated derivatives thereof were synthesized and investigated in regard to their emission behavior in solution as well as in the solid state. Depending on the nature of the incorporated substituent and its position, emission efficiencies were increased or diminished, resulting in AIE or ACQ characteristics. Single-crystal analysis revealed J- and H-type packing motifs and a so-far undescribed isolation of ESIPT-based fluorophores in the keto form.

Organic selenium salt and preparation method thereof

-

Paragraph 0021; 0025; 0029; 0030; 0037; 0038; 0045; 0046, (2019/01/08)

The invention discloses an organic selenium salt as well as a preparation method and application thereof. The molecular structural formula of the organic selenium salt is as follows: (as described inthe specification), wherein R is Na, K, Li, Mg, Ca or organic base, n represents chemical valence, - represents negative charge, and + represents positive charge. The organic selenium salt provided bythe invention has good water solubility, can be directly dissolved in water, and has a good application prospect.

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