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14068-54-3

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14068-54-3 Usage

General Description

5-BUTYL-1,3,4-THIADIAZOL-2-AMINE is a chemical compound with the molecular formula C7H13N3S. It is a thiadiazole derivative with a butyl group attached to the nitrogen atom. 5-BUTYL-1,3,4-THIADIAZOL-2-AMINE is used in organic synthesis and pharmaceutical research, and it has potential applications in the development of new drugs and agrochemicals. The presence of the thiadiazole ring in its structure gives it interesting biological activities, making it of interest to researchers in the pharmaceutical and agricultural industries. Additionally, 5-BUTYL-1,3,4-THIADIAZOL-2-AMINE might possess unique properties that could be beneficial for the development of new materials and technologies.

Check Digit Verification of cas no

The CAS Registry Mumber 14068-54-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,0,6 and 8 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 14068-54:
(7*1)+(6*4)+(5*0)+(4*6)+(3*8)+(2*5)+(1*4)=93
93 % 10 = 3
So 14068-54-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H11N3S/c1-2-3-4-5-8-9-6(7)10-5/h2-4H2,1H3,(H2,7,9)

14068-54-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-BUTYL-1,3,4-THIADIAZOL-2-AMINE

1.2 Other means of identification

Product number -
Other names 2-Amino-5-butyl-1,3,4-thiadiazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14068-54-3 SDS

14068-54-3Relevant articles and documents

N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification

Xue, Wenjie,Li, Xueyao,Ma, Guixing,Zhang, Hongmin,Chen, Ya,Kirchmair, Johannes,Xia, Jie,Wu, Song

, (2020/02/04)

Due to the occurrence of antibiotic resistance, bacterial infectious diseases have become a serious threat to public health. To overcome antibiotic resistance, novel antibiotics are urgently needed. N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides are a potential new class of antibacterial agents, as one of its derivatives was identified as an antibacterial agent against S. aureus. However, no potency-directed structural optimization has been performed. In this study, we designed and synthesized 37 derivatives, and evaluated their antibacterial activity against S. aureus ATCC29213, which led to the identification of ten potent antibacterial agents with minimum inhibitory concentration (MIC) values below 1 μg/mL. Next, we performed bacterial growth inhibition assays against a panel of drug-resistant clinical isolates, including methicillin-resistant S. aureus, and cytotoxicity assays with HepG2 and HUVEC cells. One of the tested compounds named 1-ethyl-4-hydroxy-2-oxo-N-(5-(thiazol-2-yl)-1,3,4-thiadiazol-2-yl)-1,2-dihydroquinoline-3-carboxamide (g37) showed 2 to 128-times improvement compared with vancomycin in term of antibacterial potency against the tested strains (MICs: 0.25–1 μg/mL vs. 1–64 μg/mL) and an optimal selective toxicity (HepG2/MRSA, 110.6 to 221.2; HUVEC/MRSA, 77.6–155.2). Further, comprehensive evaluation indicated that g37 did not induce resistance development of MRSA over 20 passages, and it has been confirmed as a bactericidal, metabolically stable, orally active antibacterial agent. More importantly, we have identified the S. aureus DNA gyrase B as its potential target and proposed a potential binding mode by molecular docking. Taken together, the present work reports the most potent derivative of this chemical series (g37) and uncovers its potential target, which lays a solid foundation for further lead optimization facilitated by the structure-based drug design technique.

Synthesis, characterization and biological evaluation of some novel fluoroquinolones

Pandit, Neelanjana,Shah, Kamal,Agrawal, Neetu,Upmanyu, Neeraj,Shrivastava, Sushant K.,Mishra, Pradeep

, p. 843 - 851 (2016/04/20)

Different derivatives of fluoroquinolones were synthesized by combining it with different thiadiazoles. The synthesized compounds were characterized by infrared spectroscopy, proton nuclear magnetic resonance and mass spectral data. The compounds were screened for their antibacterial and antifungal activity. Ciprofloxacin derivatives with thiadiazoles 7c showed good antibacterial as well as antifungal activities, whereas 13c and 13e showed antibacterial and antifungal activity respectively. Sparfloxacin derivative 8c showed both antibacterial and antifungal activity. Sparfloxacin derivatives 14b and 14e showed antibacterial and antifungal activity respectively.

Some novel 2-methyl-3-(1′3′4′-thiadiazoyl)-4-(3H) quinazolinones with anticonvulsant and CNS depressant activity

Mishra, Pradeep,Jatav, Varsha,Kashaw

, p. 1165 - 1170 (2008/02/07)

A series comprising six novel 2-methyl-3-(1′3′4′- thiadiazoyl)-4(3H)quinazolinones have been synthesized by condensing different 2-amino-1,3,4-thiadiazoles with 2-methyl benzoxazin-2-one and evaluated for anticonvulsant and CNS depressant activity. Compound 5f exhibited both anticonvulsant and CNS depressant activity.

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