140682-23-1

Downstream Products

• 1608116-81-9 (S)-diethyl 2-(1-(2-trifluoromethylphenyl)-3-oxo-3-phenylpropyl)malonate 
• 1608116-80-8 (R)-diethyl 2-(1-(2-trifluoromethylphenyl)-3-oxo-3-phenylpropyl)malonate 
• 140682-40-2 5-Phenyl-7-(2-trifluoromethyl-phenyl)-1,4-diaza-bicyclo[4.1.0]hept-4-ene 
• 140682-32-2 2,3-Dibromo-1-phenyl-3-(2-trifluoromethyl-phenyl)-propan-1-one 

Relevant academic research and scientific papers

Unsaturated ketone compound as well as preparation method and application thereof

The present invention relates to a novel GPR52 antagonist. Specifically, the invention relates to an unsaturated ketone compound, a pharmaceutically acceptable salt, a stereoisomer or a prodrug molecule thereof, and a method for preparing a pharmaceutical composition thereof. The invention further relates to the use of the GPR52 antagonist as an orphan G protein coupled receptor GPR52 antagonist,and further relates to the use of the GPR52 antagonist in the preparation of drugs for preventing and treating Huntington's disease.

NUCLEAR RECEPTOR MODULATORS AND THEIR USE FOR THE TREATMENT AND PREVENTION OF CANCER

Disclosed are compounds which are nuclear receptor modulators that can act as antagonists to the androgen receptor, for example, a compound of Formula I: wherein R1 to R5 and X1 to X5 are as described herein, as well as pharmaceutically acceptable salts, solvates, and stereoisomers thereof. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment for cancers, including prostate cancers, other nuclear receptor mediated cancers, and other conditions, are also disclosed.