14070-53-2Relevant academic research and scientific papers
Generation and Reactivity of Amidyl Radicals: Manganese-Mediated Atom-Transfer Reaction
Li, Jinxia,Li, Ping,Liu, Run-Zhou,Liu, Xian-Guan,Qu, Shuanglin,Sun, Jun,Zhang, Bo
supporting information, p. 4428 - 4433 (2020/02/05)
A simple and efficient protocol to generate amidyl radicals from amine functionalities through a manganese-mediated atom-transfer reaction has been developed. This approach employs an earth-abundant and inexpensive manganese complex, Mn2(CO)su
A general and atom-efficient continuous-flow approach to prepare amines, amides and imines via reactive N-chloramines
Jolley, Katherine E.,Chapman, Michael R.,John Blacker
, p. 2220 - 2228 (2018/09/04)
Chloramines are an important class of reagents, providing a convenient source of chlorine or electrophilic nitrogen. However, the instability of these compounds is a problem which makes their isolation and handling difficult. To overcome these hazards, a continuous-flow approach is reported which generates and immediately reacts N-chloramines directly, avoiding purification and isolation steps. 2-Chloramines were produced from the reaction of styrenes with N-alkyl-N-sulfonyl-N-chloramines, whilst N-alkyl or N,N’-dialkyl-N-chloramines reacted with anisaldehyde in the presence of t-BuO2H oxidant to afford amides. Primary and secondary imines were produced under continuous conditions from the reaction of N-chloramines with base, with one example subsequently reduced under asymmetric conditions to produce a chiral amine in 94% ee.
Copper-Catalyzed Silylation of C(sp3)-H Bonds Adjacent to Amide Nitrogen Atoms
Feng, Jian-Jun,Oestreich, Martin
supporting information, p. 4273 - 4276 (2018/07/29)
A copper-catalyzed C-Si bond formation between N-halogenated amides and Si-B reagents is described. This oxidative coupling enables the silylation of C(sp3)-H bonds α to an amide nitrogen atom. The utility of the new method is demonstrated for
