140700-64-7

Basic information

• Product Name: 3-IODO-BENZAZEPIN-2-ONE
• Synonyms: 3-IODO-BENZAZEPIN-2-ONE;3-IODO-4,5-DIHYDRO-1H-BENZO[B]AZEPIN-2(3H)-ONE;1,3,4,5-Tetrahydro-3-iodo-2H-1-benzazepin-2-one;3-Iodo-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one;2H-1-Benzazepin-2-one, 1,3,4,5-tetrahydro-3-iodo-;3-Iodo-2H-benzo[b]azepin-2-one;3-iodo-1-benzazepin-2-one;3-iodo-1,3,4,5-tetrahydro-1-benzazepin-2-one
• CAS NO: 140700-64-7
• Molecular Formula: C₁₀H₁₀INO
• Molecular Weight: 283.07
• Mol File: 140700-64-7.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 405.955 °C at 760 mmHg
• Flash Point: 199.315 °C
• Appearance: /
• Density: 1.77
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.661
• PKA: 13.82±0.40(Predicted)
• CAS DataBase Reference: 3-IODO-BENZAZEPIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODO-BENZAZEPIN-2-ONE(140700-64-7)
• EPA Substance Registry System: 3-IODO-BENZAZEPIN-2-ONE(140700-64-7)

Safety Data

• Hazardous Substances Data: 140700-64-7(Hazardous Substances Data)

Usage

General Description

3-IODO-BENZAZEPIN-2-ONE is a chemical compound with the molecular formula C9H6INO. It is a benzazepine derivative with a substituted iodo group. 3-IODO-BENZAZEPIN-2-ONE has potential biological activity and is used in pharmaceutical research for medicinal chemistry applications. It may have applications in the development of drugs for the treatment of certain medical conditions such as neurological disorders or neurodegenerative diseases. Additionally, it may also be utilized as a building block in organic synthesis for the creation of other more complex chemical structures.

InChI:InChI=1/C10H10INO/c11-8-6-5-7-3-1-2-4-9(7)12-10(8)13/h1-4,8H,5-6H2,(H,12,13)

Upstream product

• 4424-80-0 2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 68253-36-1 1-tetralone oxime 

Downstream Products

• 97278-68-7 3-azido-2,3,4,5-tetrahydro-2-oxo-1 H-1-benzazepine 
• 86499-35-6 3-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 
• 307335-65-5 3-[4-(4-methyl-benzyl)-piperazin-1-yl]-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 159106-96-4 [2-(1-Benzyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl)-1,1-dimethyl-ethyl]-carbamic acid tert-butyl ester 
• 159170-97-5 [2-(1-Biphenyl-4-ylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl)-1,1-dimethyl-ethyl]-carbamic acid tert-butyl ester 
• 137036-54-5 (S)-3-amino-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one 
• 137036-55-6 (R)-3-amino-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one 
• 145485-03-6 ((R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)carbamic acid tert-butyl ester 

Relevant articles and documents

Discovery of novel triazolobenzazepinones as γ-secretase modulators with central Aβ42 lowering in rodents and rhesus monkeys

Abstract Synthesis and SAR studies of novel triazolobenzazepinones as gamma secretase modulators (GSMs) are presented in this communication. Starting from our azepinone leads, optimization studies toward improving central lowering of Aβ42 led to the discovery of novel benzo-fused azepinones. Several benzazepinones were profiled in vivo and found to lower brain Aβ42 levels in Sprague Dawley rats and transgenic APP-YAC mice in a dose-dependent manner after a single oral dose. Compound 34 was further progressed into a pilot study in our cisterna-magna-ported rhesus monkey model, where we observed robust lowering of CSF Aβ42 levels.

A convergent asymmetric synthesis of a growth hormone secretagogue

Described herein is a convergent asymmetric synthesis of growth hormone secretagogue (GHS) suitable for large-scale preparations. Key features include: (1) an improved method for α-iodination of a lactam; (2) a novel synthesis of a disubstituted urea usin

Design, synthesis, and discovery of 3-piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives: A novel series of mixed dopamine D2/D4 receptor antagonists

3-Piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives (δ-lactams) were designed, synthesized, and identified as a new series of mixed dopamine D2/D4 receptor antagonists. To further the structure-activity relationship (SAR) study, 3-piperazinylindolin-2-ones (γ-lactams) and 3-piperazinyl-3H,4H,5H-benzo[f]azepin-2-ones (ε-lactams) were also prepared and examined. (C) 2000 Elsevier Science Ltd.