140701-16-2Relevant academic research and scientific papers
Manganese-Catalyzed C(α)-Alkylation of Oxindoles with Secondary Alcohols via Borrowing Hydrogen
Rana, Jagannath,Nagarasu, Palaniyappan,Subaramanian, Murugan,Mondal, Akash,Madhu, Vedichi,Balaraman, Ekambaram
supporting information, p. 627 - 634 (2021/04/02)
A general and efficient C(α)-alkylation of oxindoles with unactivated secondary alcohols as alkylating agents catalyzed by a newly developed NNN-Mn(II) complex is reported. Mechanistic studies illustrate that the importance of the NH moiety in the complex and M-L cooperation play very important roles during the catalytic transformation.
C-Alkylation of Various Carbonucleophiles with Secondary Alcohols under CoIII-Catalysis
Chakraborty, Priyanka,Garg, Nidhi,Manoury, Eric,Poli, Rinaldo,Sundararaju, Basker
, p. 8023 - 8031 (2020/08/21)
Oxindoles have been successfully α-alkylated under Cp*CoIII catalysis by a vast array of secondary alcohols, including cyclic, acyclic, symmetrical, and unsymmetrical, to produce C-alkylated oxindoles. This protocol was also extended to the α-alkylation of N,N-dimethyl barbituric acid and benzyl cyanides. The kinetic profile and other preliminary mechanistic investigations suggest a first-order reaction rate in oxindoles and catalysts. A plausible catalytic cycle is proposed on the basis of the kinetic profile, of other preliminary mechanistic investigations, and of previous mechanistic studies on similar transformations, whereas density functional theory calculations provide insight into the nature of the active species.
Pd/C-catalyzed alkylation of heterocyclic nucleophiles with alcohols through the "borrowing hydrogen" process
Putra, Anggi Eka,Oe, Yohei,Ohta, Tetsuo
, p. 7799 - 7805 (2015/12/31)
The alkylation of heterocyclic compounds is important for the synthesis of various biologically active compounds. In this paper, we present the development of a Pd/C-catalyzed alkylation of heterocyclic compounds using alcohols as the alkylating agents. T
Iridium catalysed C-3 alkylation of oxindole with alcohols under solvent free thermal or microwave conditions
Grigg, Ronald,Whitney, Simon,Sridharan, Visuvanathar,Keep, Ann,Derrick, Andrew
experimental part, p. 4375 - 4383 (2009/10/17)
Ir-catalysed alkylation of oxindole and N-methyl oxindole with a range of substituted benzyl and heteroaryl alcohols under solvent free thermal or microwave conditions afforded the corresponding C-3-monoalkylated products in high to excellent yield.
