140703-15-7

Basic information

• Product Name: S-Methyl-N,N-diethylthiocarbamate Sulfoxide
• Synonyms: S-Methyl-N,N-diethylthiocarbamoyl Sulfoxide;Methyl Diethylthiocarbamate Sulfoxide;N,N-Diethyl-1-(methylsulfinyl)-formamide;S-methyl N,N-diethylthiolcarbamate sulfoxide;S-METHYLN,N-DIETHYLTHIOLCARBAMATESULPHOXIDE;DETC MeSO
• CAS NO: 140703-15-7
• Molecular Formula: C6H13NO2S
• Molecular Weight: 163.24
• Product Categories: All Inhibitors;Inhibitors;Sulfur & Selenium Compounds
• Mol File: 140703-15-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 255.4°Cat760mmHg
• Flash Point: 108.3°C
• Appearance: /
• Density: 1.154g/cm³
• Vapor Pressure: 0.0163mmHg at 25°C
• Refractive Index: 1.512
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Stability: Light and Temperature Sensitive
• CAS DataBase Reference: S-Methyl-N,N-diethylthiocarbamate Sulfoxide(CAS DataBase Reference)
• NIST Chemistry Reference: S-Methyl-N,N-diethylthiocarbamate Sulfoxide(140703-15-7)
• EPA Substance Registry System: S-Methyl-N,N-diethylthiocarbamate Sulfoxide(140703-15-7)

Safety Data

• Hazardous Substances Data: 140703-15-7(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Oil

Uses

Different sources of media describe the Uses of 140703-15-7 differently. You can refer to the following data:
1. S-Methyl-N,N-diethylthiocarbamate Sulfoxide, is an oxygenated metabolite of Disulfiram (Antabuse) that is capable of in vitro inactivation of liver mitochondrial aldehyde dehydrogenase (EC 1.2.1.3, ALDH).
2. S-Methyl-N,N-diethylthiocarbamate Sulfoxide, is an oxygenated metabolite of Disulfiram (Antabuse) that is capable of in vitro inactivation of liver mitochondrial aldehyde dehydrogenase (EC 1.2.1.3, ALDH).This compound is suitable for aldehyde dehydrogenase (ALDH) related research.

InChI:InChI=1/C6H13NO2S/c1-4-7(5-2)6(8)10(3)9/h4-5H2,1-3H3

Upstream product

• 37174-63-3 S-Methyl N,N-diethylthiocarbamate 

Downstream Products

• 157723-51-8 S-(N,N-diethylcarbamoyl)glutathione 
• 155514-79-7 S-methyl N,N-diethylthiolcarbamate sulfone 

Relevant articles and documents

S-Methyl N,N-Diethylthiocarbamate Sulfone, a Potential Metabolite of Disulfiram and Potent Inhibitor of Low Km Mitochondrial Aldehyde Dehydrogenase

Disulfiram inhibits hepatic aldehyde dehydrogenase (ALDH) causing an accumulation of acetaldehyde after ethanol ingestion. It is thought that disulfiram is too short-lived in vivo to directly inhibit ALDH, but instead is biotransformed to reactive metabolites that inhibit the enzyme. S-Methyl N,N-diethylthiocarbamate (MeDTC) sulfoxide has been identified in the blood of animals given disulfiram and is a potent inhibitor of ALDH (Hart and Faiman, Biochem Pharmacol 46: 2285-2290, 1993). MeDTC sulfone is a logical metabolite of MeDTC sulfoxide. Therefore, we investigated the effects of MeDTC sulfone on the activity of rat hepatic low Km mitochondrial ALDH, the major enzyme in the metabolism of acetaldehyde. MeDTC sulfone inhibited the low Km mitochondrial ALDH in vitro with an IC50 of 0.42 +/- 0.04 μM (mean +/- SD, N = 5) compared with disulfiram, which had an IC50 of 7.5 +/- 1.2 μM under the same conditions. The inhibition of ALDH by MeDTC sulfone was time dependent. The decline in ALDH activity followed pseudo first-order kinetics with an apparent half-life of 2.1 min at 0.6 μM MeDTC sulfone. Inhibition of ALDH by MeDTC sulfone was apparently irreversible; dilution of the inhibited enzyme did not restore lost activity. The substrate (acetaldehyde, 80 μM) and cofactor (NAD, 0.5 mM) together completely protected ALDH from inhibition by MeDTC sulfone; substrate alone partially protected the enzyme. Addition of either thiol-containing compound glutathione (GSH) or dithiothreitol (DTT) to MeDTC sulfone before incubation with the enzyme increased the IC50 of MeDTC sulfone by 7- to 14-fold. Neither GSH nor DTT could restore lost ALDH activity after exposure of the enzyme to MeDTC sulfone. Results of these studies indicate that MeDTC sulfone, a potential metabolite of disulfiram, is a potent, irreversible inhibitor of low Km mitochondrial ALDH.