140710-12-9

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 140710-10-7 cis-2-(tert-butyldiphenylsiloxymethyl)cyclobutan-1-ol 
• 140852-37-5 (1R,2R)-2-hydroxymethylcyclobutan-1-ol 
• 140710-09-4 cis-2-hydroxymethylcyclobutan-1-ol 
• 140710-29-8 (1R,2R)-1-acetoxymethyl-2-(tert-butyldiphenylsiloxy)cyclobutane 
• 140710-08-3 2-oxo-3,5-dioxabicyclo<4.2.0>octane-4-spirocyclohexane 
• 140852-31-9 (1R,2R)-2-(tert-butyldiphenylsiloxymethyl)cyclobutan-1-ol 

Relevant academic research and scientific papers

COMPOUNDS THAT INHIBIT MCL-1 PROTEIN

Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Regio-, stereo-, and enantioselective synthesis of cyclobutanols by means of the photoaddition of 1,3-dioxin-4-ones and lipase-catalyzed acetylation

Homochiral cis-2-hydroxymethylcyclobutanols, their all cis 3-methyl, and 4-hydroxymethyl derivatives were synthesized from 1,3-dioxin-4-ones via cyclobutane ring formation by [2+2]photocycloaddition, dioxanone ring cleavage, and reduction, followed by lip