140710-94-7 Usage
Description
25-Hydroxyvitamin D3-[D3] Calcifediol-D3, also known as calcifediol, is a prohormone derived from the hydroxylation of vitamin D3 (cholecalciferol) in the liver. It serves as a precursor for the synthesis of calcitriol (1,25-dihydroxyvitamin D3 or [1,25(OH)2D3]) and is utilized as a biomarker to assess the vitamin D status in the body. The deuterated form, 25-Hydroxyvitamin D3 (6,19,19-d3), has its C-6 and C-19 protons replaced by deuterium, making it a valuable analytical standard.
Uses
1. Used in Analytical Standards:
25-Hydroxyvitamin D3-[D3] Calcifediol-D3 is used as an analytical standard for the quantitative analysis of hydroxyvitamin D3 concentration in human serum via LC-MS. This application is crucial for determining the vitamin D status in individuals and diagnosing any potential deficiencies or related health issues.
2. Used in Pharmaceutical Research:
As a prohormone, 25-Hydroxyvitamin D3-[D3] Calcifediol-D3 plays a significant role in the synthesis of calcitriol, which has various biological activities, including regulating calcium and phosphorus metabolism, immune system modulation, and cell differentiation. This makes it an essential compound in pharmaceutical research for developing treatments targeting these biological processes.
3. Used in Clinical Diagnostics:
25-Hydroxyvitamin D3-[D3] Calcifediol-D3 serves as a reliable biomarker for assessing the vitamin D status in the body. It is used in clinical diagnostics to identify potential vitamin D deficiencies, which can lead to various health issues such as rickets, osteoporosis, and immune system dysfunction.
4. Used in Nutritional Research:
Understanding the role of vitamin D in overall health and well-being is essential for developing effective nutritional strategies. 25-Hydroxyvitamin D3-[D3] Calcifediol-D3 is used in nutritional research to study the impact of vitamin D on various aspects of human health, including bone health, immune function, and chronic disease prevention.
Check Digit Verification of cas no
The CAS Registry Mumber 140710-94-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,0,7,1 and 0 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 140710-94:
(8*1)+(7*4)+(6*0)+(5*7)+(4*1)+(3*0)+(2*9)+(1*4)=97
97 % 10 = 7
So 140710-94-7 is a valid CAS Registry Number.
140710-94-7Relevant articles and documents
Synthesis of 25-hydroxy-6,19,19′-2H3vitamin D3 and 1α,25-dihydroxy-[6,19′-2H3]vitamin D3
Ray, Rahul,Vicchio, Domenick,Yergey, Alfred,Holick, Michael F.
, p. 142 - 146 (2007/10/02)
Syntheses of polydeuterated analogs of 25-hydroxyvitamin d3 and 1α,25-dihydroxy vitamin d3 are described. These analogs, containing stable isotope atoms at metabolically stable positions, are potentially useful in studies involving c
