1407151-58-9Relevant academic research and scientific papers
Unusually Stable Picoloyl-Protected Trimethylsilyl Glycosides for Nonsymmetrical 1,1′-Glycosylation and Synthesis of 1,1′-Disaccharides with Diverse Configurations
Lu, Yen-Chu Luke,Ghosh, Bhaswati,Mong, Kwok-Kong Tony
, p. 6905 - 6918 (2017/05/29)
Nonsymmetrical 1,1′-disaccharides and related derivatives constitute structural components in various glycolipids and natural products. Some of these compounds have been shown to exhibit appealing biological properties. We report a direct yet stereoselective 1,1′-glycosylation strategy for the synthesis of nonsymmetrical 1,1′-disaccharides with diverse configurations and sugar components. The strategy is based on the joined forces of a new class of configurationally stable glycoside acceptors and stereodirecting thioglycoside donors. The new glycoside acceptors feature a picoloyl (Pico) protecting group at the remote C4/C3 position that confers unusual stability on TMS glycosides under acidic conditions.
In situ formation of β-glycosyl imidinium triflate from participating thioglycosyl donors: Elaboration to disarmed-armed iterative glycosylation
Lin, Yu Hsien,Ghosh, Bhaswati,Tony Mong, Kwok-Kong
supporting information, p. 10910 - 10912,3 (2020/09/16)
β-Glycosyl imidinium triflate is generated from participating thioglycoside donors for disarmed-armed iterative glycosylations and one-pot oligosaccharide synthesis.
