1407153-97-2Relevant academic research and scientific papers
Synthesis of enantiomerically enriched imidazolidin-2-ones through asymmetric palladium-catalyzed alkene carboamination reactions
Hopkins, Brett A.,Wolfe, John P.
supporting information, p. 9886 - 9890 (2012/10/29)
Positive water effect: A catalyst composed of [Pd2(dba) 3] (dba=dibenzylideneacetone) and (S)-Siphos-PE is effective for the enantioselective coupling of N-allyl ureas with aryl bromides to afford 4-substituted imidazolidin-2-ones. Added water leads to significantly improved enantioselectivities with electron-poor aryl halide substrates. It is suggested that the C-C bond-forming reductive elimination is the enantiodetermining step in these reactions. Copyright
