14073-00-8Relevant academic research and scientific papers
Visible-Light-Mediated Enantioselective Photoreactions of 3-Alkylquinolones with 4- O-Tethered Alkenes and Allenes
Li, Xinyao,Jandl, Christian,Bach, Thorsten
, p. 3618 - 3622 (2020)
The title compounds undergo intramolecular [2 + 2] photocycloaddition reactions when irradiated with visible light in the presence of a chiral sensitizer. Up to four defined stereogenic centers are formed in a single step (14 examples with a tethered alkene, 6 examples with an allene, 72-99percent yield, 81-99percent ee) at catalyst loadings as low as 0.5 mol percent. The alkyl group in the 3-position is crucial for the success of the reaction as it leads to a significant decrease of the triplet energy.
Symmetrical bis-quinolinium compounds: New human choline kinase inhibitors with antiproliferative activity against the HT-29 cell line
Sánchez-Martín, Rosario,Campos, Joaquín M.,Conejo-García, Ana,Cruz-López, Olga,Bá?ez-Coronel, Mónica,Rodríguez-González, Agustín,Gallo, Miguel A.,Lacal, Juan C.,Espinosa, Antonio
, p. 3354 - 3363 (2007/10/03)
Studies have been aimed at the establishment of structure-activity relationships that define choline kinase inhibitory and antiproliferative activities of 40 bisquinolinium compounds. These derivatives have electron-releasing groups at position 4 of the q
