1407511-75-4Relevant academic research and scientific papers
Catalytic enantioselective O -nitrosocarbonyl aldol reaction of β-dicarbonyl compounds
Baidya, Mahiuddin,Griffin, Kimberly A.,Yamamoto, Hisashi
, p. 18566 - 18569 (2012)
The first example of a Cu-catalyzed asymmetric O-nitrosocarbonyl aldol reaction is described. This novel protocol allows convenient access to highly enantioenriched α-hydroxy-β-ketoesters including the antibacterial natural product kjellmanianone (up to 99% ee). MnO2 was introduced as a mild efficient oxidant for the in situ generation of nitrosocarbonyl species from hydroxamic acid derivatives.
