14077-58-8

Basic information

• Product Name: ethoxyacetyl chloride
• Synonyms: ethoxyacetyl chloride;Einecs 237-930-3;2-ethoxy-Acetyl chloroide;2-Ethoxyacetyl chloride, 97%, stab. with 0.3% MagnesiuM oxide;Ethoxyacetic acid chloride;Acetyl chloride,2-ethoxy-;2-Ethoxyacetyl chloride, stabilized with 0.3% Magnesium oxide
• CAS NO: 14077-58-8
• Molecular Formula: C₄H₇ClO₂
• Molecular Weight: 122.55018
• EINECS: 237-930-3
• Mol File: 14077-58-8.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 124℃
• Flash Point: 45℃
• Appearance: /
• Density: 1.119
• Vapor Pressure: 13.3mmHg at 25°C
• Refractive Index: 1.4204
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: ethoxyacetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: ethoxyacetyl chloride(14077-58-8)
• EPA Substance Registry System: ethoxyacetyl chloride(14077-58-8)

Safety Data

• HazardClass: 8
• Hazardous Substances Data: 14077-58-8(Hazardous Substances Data)

Usage

Uses

It is employed in fine chemical syntheses and used as pharmaceutical intermediates. A trace of cis-ethoxyacetamide was also detected and isolated with an authentic sample prepared from the reaction of cis-3-amino-6-methylchroman-4-01 (2) with 2-ethoxyacetyl chloride.

InChI:InChI=1/C4H7ClO2/c1-2-7-3-4(5)6/h2-3H2,1H3

Upstream product

• 79-37-8 oxalyl dichloride 
• 627-03-2 3-oxapentanoic acid 
• 60-29-7 diethyl ether 
• 101-83-7 N-cyclohexyl-cyclohexanamine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 579-94-2 ethoxy-acetic acid menthyl ester 
• 855627-23-5 2-ethoxymethyl-7-hydroxy-3-(2-methoxy-phenyl)-chromen-4-one 
• 17952-11-3 1-ethoxypentane 
• 76086-05-0 1-ethoxy-2-oxobutane 
• 628-32-0 ethylpropylether 
• 101714-28-7 1-ethoxy-2-hexanone 
• 817-95-8 ethyl 2-ethoxyethanoate 
• 51770-98-0 ethoxyethylamide 
• 38342-55-1 bis-(2-ethoxyacetoxy-ethyl)-ether 
• 134017-46-2 methyl (2-ethoxyacetamido)benzoate 
• 812631-94-0 N-[2-(7-benzyloxy-2-ethoxymethyl-1H-imidazo[4,5-c]quinolin-1-yl)-1,1-dimethylethyl]methanesulfonamide 

Relevant articles and documents

Immobilization engineering-How to design advanced sol-gel systems for biocatalysis?

An immobilization engineering approach using bioinformatics and experimental design tools was applied to improve the sol-gel enzyme entrapment methodology. This strategy was used for the immobilization of lipase B from Candida antarctica (CaLB), a versatile enzyme widely used even on the industrial scale. The optimized entrapment of CaLB in sol-gel matrices is reported by the response-surface methodology enabling efficient process development. The immobilized CaLBs characterized by functional efficiency and enhanced recovery provided economical and green options for flow chemistry. Various ternary mixtures of sol-gel precursors allowed the creation of tailored entrapment matrices best suited for the enzyme and its targeted substrate. The sol-gel-entrapped forms of CaLB were excellent biocatalysts in the kinetic resolutions of secondary alcohols and secondary amines with aromatic or aliphatic substituents both in batch and continuous-flow biotransformations.

Selectivities in the reaction of vicinal diimines and acyl chlorides

The reaction of vicinal diimines and acyl chlorides in the presence of triethylamine produces 3-imino-β-lactams and/or bis-β-lactams chemo-, regio-, and stereoselectively, which are important intermediates in pharmaceutical and organic synthesis. The selectivities in the reaction have been investigated. The results indicate that all diimines react with various ketenes generated from acyl chlorides in the presence of triethylamine to give rise to cis-4-imino-β-lactams (mono-cis-β-lactams) diastereoselectively due to the electron-withdrawing property of the imino group in the vicinal diimines. Bis-β-lactams were obtained from diimines via the mono-cis-β-lactams as intermediates. Only ketenes with strong electron-donating substituents can react with the mono-cis-β-lactams to yield bis-β-lactams, affording a pair of C2-symmetric cis-bis-β- lactams with symmetric diimines, two or four pairs of diastereomeric bis-β-lactams with ketoaldehyde-derived unsymmetric diimines depending on the steric hindrance of their N-substituents. The current investigation provides very important information for the selective preparation of mono- and bis-β-lactams from vicinal diimines.

HETEROCYCLIC COMPOUND

Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

2-AMINO-QUINOLINE DERIVATIVES

Described herein are 2-amino-quinoline derivatives that are agonists of toll-like receptors 7 and 8 (TLR7/8), pharmaceutical compositions, and methods of use of the compounds and compositions to treat various diseases, such as viral, cancer, and allergic diseases, in need thereof by administering a therapeutically effective amount of a 2-amino-quinoline derivative.