14080-51-4

Basic information

• Product Name: 2-AMINO-THIOPHENE-3-CARBOXYLIC ACID AMIDE
• Synonyms: TIMTEC-BB SBB007065;2-AMINOTHIOPHENE-3-CARBOXAMIDE;2-AMINO-THIOPHENE-3-CARBOXYLIC ACID AMIDE;2-AMINO-3-THIOPHENECARBOXAMIDE;AKOS B014696;AKOS 93830;ART-CHEM-BB B014696;CHEMBRDG-BB 3014696
• CAS NO: 14080-51-4
• Molecular Formula: C₅H₆N₂OS
• Molecular Weight: 142.18
• Mol File: 14080-51-4.mol
• Article Data: 21

Chemical Properties

• Melting Point: 153-155°C
• Boiling Point: 321.77 °C at 760 mmHg
• Flash Point: 148.402 °C
• Appearance: /
• Density: 1.423 g/cm³
• Vapor Pressure: 0.000292mmHg at 25°C
• Refractive Index: 1.681
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 15.58±0.50(Predicted)
• CAS DataBase Reference: 2-AMINO-THIOPHENE-3-CARBOXYLIC ACID AMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-THIOPHENE-3-CARBOXYLIC ACID AMIDE(14080-51-4)
• EPA Substance Registry System: 2-AMINO-THIOPHENE-3-CARBOXYLIC ACID AMIDE(14080-51-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 14080-51-4(Hazardous Substances Data)

Usage

General Description

2-Amino-thiophene-3-carboxylic acid amide, also known as 3-Aminothiophene-2-carboxamide, is a chemical compound with the molecular formula C5H6N2O2S. It is an amide derivative of thiophene carboxylic acid and contains an amino group attached to the thiophene ring. 2-AMINO-THIOPHENE-3-CARBOXYLIC ACID AMIDE is mainly used in organic synthesis, pharmaceutical research, and as a building block for the synthesis of various biologically active compounds. It exhibits a wide range of biological activities and has potential applications in the pharmaceutical industry for the development of new drugs. Additionally, it is also used as a chemical intermediate in the production of various agrochemicals, dyes, and pharmaceuticals.

InChI:InChI=1/C5H6N2OS/c6-4(8)3-1-2-9-5(3)7/h1-2H,7H2,(H2,6,8)

Upstream product

• 75-07-0 acetaldehyde 
• 107-91-5 cyanoacetic acid amide 
• 40018-26-6 1,4-dithiane-2,5-diol 
• 6851-93-0 thioacetaldehyde 

Downstream Products

• 354812-10-5 2-[(aminocarbonyl)amino]-5-bromo-3-thiophenecarboxamide 
• 507475-17-4 2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide 

Relevant articles and documents

A novel series of positive modulators of the AMPA receptor: Discovery and structure based hit-to-lead studies

Starting from an HTS derived hit 1, application of biostructural data facilitated rapid optimization to lead 22, a novel AMPA receptor modulator. This is the first demonstration of how structure based drug design can be exploited in an optimization program for a glutamate receptor.

Concise synthesis of tpca-1 and related thiophene-carboxamides by cross coupling

A synthesis of 5-substituted 2-[(aminocarbonyl)amino]-3-thiophene-carboxamides is described. The coupling reaction of 2-ureidothiophene-3-carboxamide and various aryl compounds allows the concise approach of promising candidates for IKK-2 inhibitor, such as TPCA-1.

Thiazole formation through a modified Gewald reaction

The synthesis of thiazoles and thiophenes starting from nitriles, via a modified Gewald reaction has been studied for a number of different substrates. 1,4-Dithiane-2,5-diol was used as the aldehyde precursor to give either 2-substituted thiazoles or 2-substituted aminothiophenes depending on the substitution of the α-carbon to the cyano group.