1408005-53-7Relevant academic research and scientific papers
Compounds having anti-Alzheimer's disease effect, and preparation method and application thereof
-
Paragraph 0036; 0037; 0038; 0109; 0110; 0111, (2017/02/09)
The invention discloses a series of compounds having an anti-Alzheimer's disease effect; o-aminobenzoic acid as a raw material is subjected to a reaction with cyclohexanone to obtain 9-chloro-1,2,3,4-tetrahydro acridine, and then 9-chloro-1,2,3,4-tetrahydro acridine is subjected to a reaction with ethylenediamine to obtain 9-(beta-amino ethylenediamine)-1,2,3,4-tetrahydro acridine; then 9-(beta-amino ethylenediamine)-1,2,3,4-tetrahydro acridine is subjected to a reaction with cinnamic acid and derivatives thereof to prepare a series of compounds having the anti-Alzheimer's disease effect; the whole process has the advantages of reasonable design, high yield, fewer by-products, and low cost; the prepared compounds have the advantages of high purity and good anti-Alzheimer's disease effect, and can realize industrialized mass production.
Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease
Chao, Xiaojuan,He, Xixin,Yang, Yilin,Zhou, Xie,Jin, Minghua,Liu, Shu,Cheng, Zhiyi,Liu, Peiqing,Wang, Yuting,Yu, Jianchen,Tan, Yi,Huang, Yingjuan,Qin, Jian,Rapposelli, Simona,Pi, Rongbiao
, p. 6498 - 6502 (2012/11/07)
A novel series of tacrine-caffeic acid hybrids (5a-f) were designed and synthesized by combining caffeic acid (CA) with tacrine. The antioxidant study revealed that all the hybrids have much more antioxidant capacities compared to CA. Among these compound
