1408063-18-2

Upstream product

• 792-74-5 4,4'-biphenyldicarboxylic acid dimethyl ester 
• 1007568-39-9 dimethyl 2-nitro-[1,1’-biphenyl]-4,4’-dicarboxylate 
• 1027000-72-1 dimethyl 2-azido-4,4’-biphenyl dicarboxylate 
• 1240557-01-0 2-amino-[1,1′-biphenyl]-4,4′-dicarboxylic acid 

Relevant academic research and scientific papers

Strain-promoted "click" modification of a mesoporous metal-organic framework

Strain-promoted "click" chemistry is used to post-synthetically modify the pore walls of azide-functionalized mesoporous bio-MOF-100 (N 3-bio-MOF-100). The reactions proceed in high yield and produce no byproduct. This new method was used to introduce various functional groups into the MOF mesopores, including succinimidyl ester bioconjugation moieties that allow for straightforward coupling of biomolecules to the pore walls.

Synthesis and click modification of an azido-functionalized Zr(iv) metal-organic framework and a catalytic study

An azido-functionalized Zr(ii) metal-organic framework (MOF), UiO-67-N3, was synthesized from 2-azidobiphenyl-4,4′-dicarboxylic acid. During the synthesis, the ligand can undergo in situ thermocyclization to give 9H-carbazole-2,7-dicarboxylic acid. It proved that UiO-67-N3 can be obtained at relatively low temperature without ligand transformation. Post-synthetic modification of UiO-67-N3 was successfully performed via the click reactions between the azido group and different alkyne compounds to produce new MOFs with different functionalities, UiO-67-Tz-X with X = COOCH3, OH and NH2. These clicked MOFs, especially UiO-67-Tz-NH2, exhibit better stability than the mother material UiO-67-N3. The catalytic properties of the clicked MOFs were studied using the Knoevenagel condensation reactions between benzaldehyde and different methylene compounds. Only the NH2-functionalized MOF is active, suggesting that the amino group, rather than the triazole group or any other component of the framework, is the crucial active site. The catalysis is heterogeneous. The MOF is recyclable for the reaction with malononitrile but not for the reaction with ethyl cyanoacetate. The deactivation in the latter case is proposed to be because the amino site reacts with the ester group of ethyl cyanoacetate to form amide. This journal is

Post synthetic exchange enables orthogonal click chemistry in a metal organic framework

Biphenyl-4,4′-dicarboxylic acid derivatives containing either azide or acetylene functional groups were inserted into UiO-67 metal organic frameworks (MOFs) via post synthetic linker exchange. Sequential and orthogonal click reactions could be performed o

Synthesis and post-synthetic modification of amine-, alkyne-, azide- and nitro-functionalized metal-organic frameworks based on DUT-5

Functionalized 4,4′-biphenyldicarboxylic acid molecules with additional amine, alkyne, azide or nitro groups were prepared and applied in the synthesis of novel metal-organic frameworks and mixed-linker metal-organic frameworks isoreticular to DUT-5. The properties of the frameworks could be tuned by varying the number of functional groups in the materials and the amine groups were employed in post-synthetic modification reactions without changing the framework structure or significantly decreasing the porosity of the materials.