1408064-71-0

Basic information

• Product Name: JNK inhibitor
• Synonyms: JNK-IN-7;3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide;JNK inhibitor
• CAS NO: 1408064-71-0
• Molecular Formula: C28H27N7O2
• Molecular Weight: 493.55968
• Product Categories: MAPK
• Mol File: 1408064-71-0.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.301±0.06 g/cm3(Predicted)
• Solubility: ≥24.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
• PKA: 13.34±0.70(Predicted)
• CAS DataBase Reference: JNK inhibitor(CAS DataBase Reference)
• NIST Chemistry Reference: JNK inhibitor(1408064-71-0)
• EPA Substance Registry System: JNK inhibitor(1408064-71-0)

Safety Data

• Hazardous Substances Data: 1408064-71-0(Hazardous Substances Data)

Usage

Description

JNK inhibitor is a potent and selective inhibitor of JNK2 and JNK3, which are members of the mitogen-activated protein kinase (MAPK) family. These inhibitors play a crucial role in regulating cellular responses to various stimuli, including stress, inflammation, and apoptosis. JNK inhibitors, such as JNK inhibitor VII, are potent and non-selective, inhibiting all three JNK isoforms (JNK1, JNK2, and JNK3) with high affinity. They are used in various applications, particularly in the field of neuroresearch and neuroprotection.

Uses

Used in Neuroresearch:
JNK inhibitor is used as a research tool for studying the role of JNKs in neuronal function and dysfunction. The expression is: JNK inhibitor is used as a research tool for understanding the role of JNKs in neuronal function and dysfunction.
Used in Neuroprotection:
JNK inhibitor is used as a neuroprotective agent to prevent neuronal damage and cell death caused by various stressors, such as oxidative stress, inflammation, and excitotoxicity. The expression is: JNK inhibitor is used as a neuroprotective agent to prevent neuronal damage and cell death.
Used in Drug Development:
JNK inhibitors are used in the development of therapeutic drugs targeting neurodegenerative diseases, such as Alzheimer's, Parkinson's, and Huntington's disease, where JNK activation has been implicated in disease progression. The expression is: JNK inhibitor is used as a drug development target for neurodegenerative diseases.
Used in Cell Signaling Studies:
JNK inhibitors are used in cell signaling research to investigate the role of JNKs in various cellular processes, including cell proliferation, differentiation, and apoptosis. The expression is: JNK inhibitor is used as a cell signaling research tool to study the role of JNKs in cellular processes.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, JNK inhibitors are used as potential therapeutic agents for the treatment of various diseases, including neurodegenerative disorders, inflammatory conditions, and cancer. The expression is: Used in Pharmaceutical Industry, JNK inhibitor is used as a potential therapeutic agent for the treatment of various diseases.
Used in Toxicology Studies:
JNK inhibitors are used in toxicology research to evaluate the effects of various toxicants on cellular JNK signaling pathways and to identify potential targets for intervention in cases of toxicant-induced cell damage. The expression is: JNK inhibitor is used as a tool in toxicology research to study the effects of toxicants on JNK signaling pathways.

references

[1]. zhang t, inesta-vaquera f, niepel m et al. discovery of potent and selective covalent inhibitors of jnk. chem biol. 2012 jan 27;19(1):140-54. [2]. goh et, arthur js, cheung pc et al. identification of the protein kinases that activate the e3 ubiquitin ligase pellino 1 in the innate immune system. biochem j. 2012 jan 1;441(1):339-46.