1408065-19-9Relevant articles and documents
Optimisation of BACE1 inhibition of tripartite structures by modification of membrane anchors, spacers and pharmacophores - Development of potential agents for the treatment of Alzheimer's disease
Linning, Philipp,Haussmann, Ute,Beyer, Isaak,Weidlich, Sebastian,Schieb, Heinke,Wiltfang, Jens,Klafki, Hans-Wolfgang,Kn?lker, Hans-Joachim
, p. 8216 - 8235 (2012/11/07)
Systematic variation of membrane anchor, spacer and pharmacophore building blocks leads to an optimisation of the inhibitory effect of tripartite structures towards BACE1-induced cleavage of the amyloid precursor protein (APP). The Royal Society of Chemis