1408075-48-8

Usage

Uses

Used in Pharmaceutical Industry:
trans-Methyl 3-hydroxy-1-methylcyclobutanecarboxylate is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs and medications, contributing to advancements in healthcare.
Used in Organic Synthesis:
In the field of organic synthesis, trans-Methyl 3-hydroxy-1-methylcyclobutanecarboxylate serves as a valuable building block for the creation of complex organic molecules. Its functional groups enable a wide range of chemical reactions, facilitating the synthesis of diverse organic compounds.
However, it is important to note that trans-Methyl 3-hydroxy-1-methylcyclobutanecarboxylate may pose health hazards and environmental risks if not properly managed and disposed of. Therefore, handling this chemical with caution and adhering to safety protocols is essential to minimize potential risks.

Upstream product

• 15760-37-9 1-Methyl-3-methylen-cyclobutancarbonsaeure-methylester 
• 1408075-88-6 methyl 1-methyl-3-oxo-cyclobutanecarboxylate 

Relevant academic research and scientific papers

Synthesis of Electron-Deficient Heteroaromatic 1,3-Substituted Cyclobutyls via Zinc Insertion/Negishi Coupling Sequence under Batch and Automated Flow Conditions

Synthesis of 1,3-substituted cyclobutyls enabled by zinc insertion into functionalized iodocyclobutyl derivatives followed by Negishi coupling with halo-heteroaromatics is reported. Two distinct sets of conditions were developed; the first involved a two-step batch protocol using activated Rieke zinc, and the second involved a multistep continuous flow process. Both methods showed complementarity and allowed for rapid access to these medicinally relevant motifs, the possibility of scaling up, and automation for library synthesis.

Benzimidazole derivatives

This invention provides compounds which are represented by a general formula [I] [in which X stands for hydrogen or halogen; B stands for halogen, cyano or optionally fluorine-substituted lower alkyl; D stands for a 3-10 membered aliphatic nitrogen-containing heterocyclic group; R3, R4 and R5 may be same or different, and each stands for hydrogen, lower alkyl optionally having substituent group(s) and the like; and a is 0 or 1]. These compounds exhibit high affinity to nociceptin receptors and whereby inhibit actions of nociceptin, and are useful as an analgesic, antiobestic, agent for ameliorating brain function, treating agents for Alzheimer's disease and dementia, and therapeutic agents for schizophrenia, neurodegenerative diseases, depression, diabetes insipidus, polyuria, hypotension and the like.

THE TORQUOSELECTIVITY OF ELECTROCYCLIC REACTIONS OF 3-DONOR-3-ACCEPTOR-SUBSTITUTED CYCLOBUTENES

Theory predicts that electron donors have larger outward rotation preferences than acceptors in thermal ring opening of cyclobutenes.Experimental verifications are presented for several 3,3-disubstituted cyclobutenes.