1408154-77-7Relevant academic research and scientific papers
Stereoselective synthesis of methyl branched chiral deoxypropionate units: A new route for synthesis of insect pheromone (-)-lardolure and (2R,4R,6R,8R) 2,4,6,8-tetramethylundecanoic acid
Yadav, J. S.,Sengupta, Sandip,Yadav, Nagendra Nath,Narasimha Chary, D.,Al Ghamdi, Ahmad Alkhazim
, p. 5952 - 5954,3 (2012)
(-)-Lardolure and (2R,4R,6R,8R)-2,4,6,8-tetramethylundecanoic acid have been synthesized via lipase catalyzed desymmetrization strategy to create two methyl chiral centers. Other key steps involved in the synthesis are Wittig reaction, Evan's asymmetric alkylation, Grignard reaction, Pd-catalyzed isomerization of primary allylic alcohol to corresponding saturated aldehyde, and PhNO/proline catalyzed MacMillan α-hydroxylation.
