1408193-46-3Relevant academic research and scientific papers
Macrocyclic compounds as anti-cancer agents: Design and synthesis of multi-acting inhibitors against HDAC, FLT3 and JAK2
Ning, Cheng-Qing,Lu, Cheng,Hu, Liang,Bi, Yan-Jing,Yao, Lei,He, Yu-Jun,Liu, Li-Fei,Liu, Xiao-Yu,Yu, Nie-Fang
, p. 104 - 115 (2015)
A novel series of macrocyclic compounds were designed and synthesized as multi-target inhibitors targeting HDAC, FLT3 and JAK2. Some of these compounds exhibited potent HDAC inhibition as well as FLT3 and JAK2 inhibition under both cell-free and cellular conditions. In vitro antiproliferative assay indicated that these compounds were interestingly more cytotoxic to MV4-11 cells bearing FLT3-ITD mutation and HEL cells bearing JAK2V617F mutation.
