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1408238-36-7

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1408238-36-7 Usage

Uses

Des-(N-2-pyridyl-β-alanine ethyl ester) Dabigatran etexilate 5-ethyl carboxylate is a derivative of Dabigatran (D100090), an oral thrombin inhibitor used to prevent venous thromboembolism.

Check Digit Verification of cas no

The CAS Registry Mumber 1408238-36-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,0,8,2,3 and 8 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1408238-36:
(9*1)+(8*4)+(7*0)+(6*8)+(5*2)+(4*3)+(3*8)+(2*3)+(1*6)=147
147 % 10 = 7
So 1408238-36-7 is a valid CAS Registry Number.

1408238-36-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 1H-?Benzimidazole-?5-?carboxylic acid, 2-?[[[4-?[[[(hexyloxy)?carbonyl]?amino]?iminomethyl]?phenyl]?amino]?methyl]?-?1-?methyl-?, ethyl ester

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1408238-36-7 SDS

1408238-36-7Downstream Products

1408238-36-7Relevant articles and documents

Preparation method of anticoagulant drug dabigatran etexilate and analogues thereof

-

Paragraph 0060; 0062; 0069-0070, (2020/05/01)

The invention discloses a preparation method of an anticoagulant drug dabigatran etexilate and analogues thereof. The preparation method comprises the following steps: 3-[(3-amino-4-methylaminobenzoyl)pyridin-2-ylamino]propionic acid ethyl ester (DGM1) and isopropyl 2-(4-cyanophenylamino)acetate (DGM2) which are taken as reaction initial raw materials undergo a docking reaction under the action ofan alkali reagent and a condensing agent to prepare an intermediate DG1; the intermediate DG1 reacts in an alcohol solvent to produce imino ester, and acid catalysis and ammonia reaction are carriedout to prepare a formamidine compound; an intermediate DG2 reacts with n-hexyl chloroformate under the action of the alkali reagent to remove one molecule of water and form an amido bond in order to obtain dabigatran etexilate; and the dabigatran etexilate analogues DG-D1 to DG-D4 are prepared from the dabigatran etexilate and its intermediate DG2. The preparation method of the dabigatran etexilate and analogues thereof has the advantages of short and feasible synthesis route, simplicity in operation, high product yield is high, and suitableness for large-scale industrial production.

Synthesis, characterization and suppression of impurities during optimization of dabigatran etexilate

Chen, Yu,Liang, Jun,Chen, Huansheng,Yuan, Li

, p. 1699 - 1710 (2013/09/12)

The synthetic methods for two impurities of dabigatran etexilate are firstly described, and both of two impurities are characterized by NMR and MS spectral data. The suppression of impurities as well as the optimization process of dabigatran etexilate is also disclosed.

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