1408251-01-3Relevant academic research and scientific papers
Palladium-catalyzed synthesis of isocoumarins and phthalides via tert -butyl isocyanide insertion
Fei, Xiang-Dong,Ge, Zhi-Yuan,Tang, Ting,Zhu, Yong-Ming,Ji, Shun-Jun
, p. 10321 - 10328 (2012)
A novel and highly efficient strategy for the synthesis of isocoumarins and phthalides through a palladium(0)-catalyzed reaction incorporating tert-butyl isocyanide has been developed. This process, providing one of the simplest methods for the synthesis of this class of valuable lactones, involves two steps including cyclization reaction and simple acid hydrolysis. The methodology is tolerant of a wide range of substrates and applicable to library synthesis.
Palladium-catalyzed carbonylative synthesis of isocoumarins and phthalides by using phenyl formate as a carbon monoxide source
Yuan, Qing,Chen, Zhen-Bang,Zhang, Fang-Ling,Zhu, Yong-Ming
, p. 1628 - 1635 (2017/02/23)
A simple and efficient palladium-catalyzed intramolecular carbonylative synthesis of isocoumarins and phthalides from the easily available starting materials by employing phenyl formate as a CO surrogate has been achieved. The approach affords target compounds in good to excellent yields with the advantages of lower toxicity, milder conditions, easy operation and wide functional group tolerance.
New method for the synthesis of lactones via nickel-catalyzed isocyanides insertion
Fei, Xiang-Dong,Tang, Ting,Ge, Zhi-Yuan,Zhu, Yong-Ming
, p. 3262 - 3271 (2013/10/01)
A novel nickel catalyst for the reaction of tert-butyl isocyanide insertion was discovered. In this approach, 1,2-bis(diphenylphosphino)ethane (L3) serves as an efficient ligand, thereby allowing the preparation of lactones from (o-bromophenyl)phenylethanone derivatives. It is noteworthy that this is the first example of nickel acting as a metal catalyst in the reactions of tert-butyl isocyanide insertion. The significance of this methodology may draw many chemists attention in the field of isocyanide-incorporating reactions. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]
