1408290-39-0

Basic information

• Product Name: 1-benzyl-4-(2-ethoxy-2-oxoethyl)-4-((2,4,6-trimethylbenzyl)thio)piperidin-1-ium chloride
• Synonyms: 1-benzyl-4-(2-ethoxy-2-oxoethyl)-4-((2,4,6-trimethylbenzyl)thio)piperidin-1-ium chloride
• CAS NO: 1408290-39-0
• Molecular Weight: 462.096
• Mol File: 1408290-39-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-benzyl-4-(2-ethoxy-2-oxoethyl)-4-((2,4,6-trimethylbenzyl)thio)piperidin-1-ium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-(2-ethoxy-2-oxoethyl)-4-((2,4,6-trimethylbenzyl)thio)piperidin-1-ium chloride(1408290-39-0)
• EPA Substance Registry System: 1-benzyl-4-(2-ethoxy-2-oxoethyl)-4-((2,4,6-trimethylbenzyl)thio)piperidin-1-ium chloride(1408290-39-0)

Safety Data

• Hazardous Substances Data: 1408290-39-0(Hazardous Substances Data)

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 21411-42-7 2,4,6-trimethylbenzyl mercaptan 
• 40110-55-2 ethyl 2-(1-benzylpiperidine-4-ylidene)acetate 

Downstream Products

• 1408290-44-7 2-(1-benzyl-4-((2,4,6-trimethylbenzyl)thio)piperidin-4-yl)ethanol 
• 1408290-49-2 1-benzyl-4-((2,4,6-trimethylbenzyl)thio)quinuclidin-1-ium chloride 
• 1408616-34-1 4-((2,4,6-trimethylbenzyl)thio)quinuclidine 
• 1408616-24-9 ethyl 2-(1-benzyl-4-((2,4,6-trimethylbenzyl)thio)piperidin-4-yl)acetate 

Relevant articles and documents

Synthesis of the pleuromutilin antibiotic SB-268091: A new practical and efficient synthesis of quinuclidine-4-thiol

A synthesis of the pleuromutilin antibiotic SB-268091 is described which includes a new and improved route to the quinuclidine-4-thiol ligand. This chemistry has been run on multikilo scale and involved a reductive double debenzylation using sodium in liquid ammonia. Alternative conditions have been developed to prepare quinuclidine-4-thiol which avoid the use of sodium in liquid ammonia. The generality of this process to prepare differentially S-protected quinuclidine-4-thiols is also discussed and exemplified by the preparation of a range of analogues.