1408337-22-3Relevant academic research and scientific papers
Synthesis of chiral sulfoximine-based thioureas and their application in asymmetric organocatalysis
Frings, Marcus,Thome, Isabelle,Bolm, Carsten
, p. 1443 - 1451 (2012/10/29)
For the first time, chiral sulfoximine derivatives have been applied as asymmetric organocatalysts. In combination with a thioureatype backbone the sulfonimidoyl moiety leads to organocatalysts showing good reactivity in the catalytic desymmetrization of a cyclic meso-anhydride and moderate enantioselectivity in the catalytic asymmetric Biginelli reaction. Straightforward synthetic routes provide the newly designed thiourea-sulfoximine catalysts in high overall yields without affecting the stereohomogeneity of the sulfur-containing core fragment.
