140860-87-3

Upstream product

• 35443-99-3 1-(4-Chloro-phenyl)-4,4,4-trifluoro-3-trifluoromethyl-but-2-en-1-one 
• 140860-81-7 4,4-difluoro-1-(4-chlorophenyl)-3-(trifluoromethyl)but-3-en-1-one 

Downstream Products

• 143541-31-5 4-[5-(4-Chloro-phenyl)-3-trifluoromethyl-furan-2-yl]-morpholine 
• 143541-28-0 [5-(4-Chloro-phenyl)-3-trifluoromethyl-furan-2-ylsulfanyl]-acetic acid methyl ester 
• 1008531-70-1 5-(4-chlorophenyl)-2-[(2-hydroxyethyl)methylamino]-3-(trifluoromethyl)furan 

Relevant academic research and scientific papers

Partially fluorinated heterocycles from 4,4-bis(trifluoromethyl)-hetero-1, 3-dienes via C-F bond activation - Synthesis of 2-fluoro-3-(trifluoromethyl) furans

An efficient synthesis of 2-fluoro-3-(trifluoromethyl)furans was developed. Keystep of the reaction sequence is a [4 + 1] cycloaddition reaction of tin(II)chloride to 4,4-bis(trifluoromethyl)-1-oxabuta-1,3-dienes. At elevated temperatures the tin heterocy

Synthesis of 3-Trifluoromethylfurans from β,β-Bis(trifluoromethyl) α,β-Unsaturated Ketones and Tin(II) Chloride

A new building block strategy for the syntheisi of 3-trifluoromethyl-substituted furans 9 and 10 is described from β,β-bis(trifluoromethyl) α,β-unsaturated ketones 2 via reductive fluoride elimination and 1,5-electrocyclization with elimination.