14087-90-2Relevant academic research and scientific papers
2-Aminotetralones: Novel inhibitors of MurA and MurZ
Dunsmore, Colin J.,Miller, Keith,Blake, Katy L.,Patching, Simon G.,Henderson, Peter J.F.,Garnett, James A.,Stubbings, William J.,Phillips, Simon E.V.,Palestrant, Deborah J.,Angeles, Joseph De Los,Leeds, Jennifer A.,Chopra, Ian,Fishwick, Colin W.G.
, p. 1730 - 1734 (2008/12/20)
Several 2-aminotetralones were identified as novel inhibitors of the bacterial enzymes MurA and MurZ. A number of these inhibitors demonstrated antibacterial activity against Staphylococcus aureus and Escherichia coli with MICs in the range 8-128 μg/ml. B
Catalytic cross-coupling of alkylzinc halides with α-chloroketones
Malosh, Chrysa F.,Ready, Joseph M.
, p. 10240 - 10241 (2007/10/03)
The cross-coupling of alkylzinc halides with α-chloroketones catalyzed by Cu(acac)2 is described. Using this method, primary and secondary alkyl groups are introduced adjacent to a ketone carbonyl under mild reaction conditions and in good yield. Cyclic, acyclic, aromatic, and aliphatic α-chloroketones are suitable substrates. Optically active α-chloroketones are converted to optically active products. The reaction was found to proceed stereospecifically with inversion of stereochemistry. The reaction is proposed to occur by direct substitution of the chloride with the alkyl group of an organocopper, -magnesium, or -zinc species. Copyright
