14088-98-3

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-Chlorophenyl)imidazolidin-2-one is used as an analgesic for the management of pain associated with conditions like arthritis, menstrual cramps, and post-surgical pain due to its ability to alleviate pain by reducing inflammation and prostaglandin production.
1-(3-Chlorophenyl)imidazolidin-2-one is used as an anti-inflammatory agent to reduce inflammation in various conditions, working by inhibiting the production of prostaglandins, which are crucial in the inflammatory process.

InChI:InChI=1/C9H9ClN2O/c10-7-2-1-3-8(6-7)12-5-4-11-9(12)13/h1-3,6H,4-5H2,(H,11,13)

Upstream product

• 120-93-4 imidazolidone 
• 625-99-0 3-iodochlorobenzene 

Downstream Products

• 62868-28-4 1-chlorocarbonyl-2-oxo-3-m-chlorophenyl-imidazolidine 
• 51940-79-5 1-(3-chloro-phenyl)-3-[2-(3,3-dipropyl-azetidin-1-yl)-ethyl]-imidazolidin-2-one 
• 51940-78-4 Zetidoline 

Relevant academic research and scientific papers

Mild, convenient and versatile Cu-mediated synthesis of N-aryl-2-imidazolidinones

A mild, general, convenient and practical methodology for the selective copper-mediated mono N-arylation of unprotected 2-imidazolidinone was developed. Strong electron-donating groups and free hydroxy and amino groups on the aryl iodide substrates were well tolerated. The use of n-butanol as the solvent for the copper-catalysed mono-arylation of 2-imidazolidinone is unprecedented.

Preparation of N-substituted imidazolidinones and N-substituted 2-thionimidazolidinones

The invention is a process for the preparation of N-substituted imidazolidinones and N-substituted 2-thionimidazolidinones which comprises contacting an oxazolidinone with a compound containing a nitrogen directly bonded to a carbonyl or a thiocarbonyl group in the presence of a Lewis acid catalyst or the hydrate of a Lewis acid catalyst under conditions such that an N-substituted imidazolidinone or N-substituted 2-thionimidazolidinone is prepared. The compound containing a nitrogen directly bonded to a carbonyl or a thiocarbonyl group is an isocyanate or isothiocyanate or a compound wherein the nitrogen is reactive and the carbonyl or thiocarbonyl group is further bonded to a substituent by a bond which is clevable under the reaction conditions. The Lewis acid catalyst corresponds to the formula wherein M is a group IB-VIIIB, IIIA or IVA element with the proviso that M is not C or Si; X is a halogen; and n is 2, 3 or 4.