140885-98-9Relevant academic research and scientific papers
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors
Chimenti, Franco,Fioravanti, Rossella,Bolasco, Adriana,Chimenti, Paola,Secci, Daniela,Rossi, Francesca,Yá?ez, Matilde,Orallo, Francisco,Ortuso, Francesco,Alcaro, Stefano,Cirilli, Roberto,Ferretti, Rosella,Sanna, M. Luisa
experimental part, p. 1273 - 1279 (2010/04/24)
A new series of synthetic flavones, thioflavones, and flavanones has been synthesized and evaluated as potential inhibitors of monoamine oxidase isoforms (MAO-A and -B). The most active series is the flavanone one with higher selective inhibitory activity against MAO-B. Some of these flavanones (mainly the most effective) have been separated and tested as single enantiomers. In order to investigate the MAOs recognition of the most active and selective compounds, a molecular modeling study has been performed using available Protein Data Bank (PDB) structures as receptor models for docking experiments.
BENZO-γ-PYRONES, PART XIV. REACTION OF C-SUBSTITUTED 2-PHENYL-4H-1-BENZOPYRAN-4-ONES WITH HYDROXYLAMINE
Basinski, Wlodzimierz
, p. 1619 - 1632 (2007/10/02)
The reaction of C-6,7,8 (CH3, Br) and C-4' (OCH3) substituted flavones 1a-1f with hydroxylamine in anhydrous pyridine has been investigated.The oximes 2a-2f and isoxazoles 3a-3f were obtained.It has been established that the ratio of oxime to isoxazole de
