140925-24-2

Basic information

• Product Name: 2H-1,4-Oxazin-2-one,3,6-dihydro-3,5-dimethyl-(9CI)
• Synonyms: 2H-1,4-Oxazin-2-one,3,6-dihydro-3,5-dimethyl-(9CI)
• CAS NO: 140925-24-2
• Molecular Formula: C₆H₉NO₂
• Molecular Weight: 127.14116
• Product Categories: GLYCINESCAFFOLD
• Mol File: 140925-24-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2H-1,4-Oxazin-2-one,3,6-dihydro-3,5-dimethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,4-Oxazin-2-one,3,6-dihydro-3,5-dimethyl-(9CI)(140925-24-2)
• EPA Substance Registry System: 2H-1,4-Oxazin-2-one,3,6-dihydro-3,5-dimethyl-(9CI)(140925-24-2)

Safety Data

• Hazardous Substances Data: 140925-24-2(Hazardous Substances Data)

Upstream product

• 140867-35-2 (+/-)-2'-oxopropyl-N-tert-butyloxycarbonylalaninate 
• 140867-38-5 (1R*,4R*,5R*,5'S*)-5-<5'-(3',5'-dimethyl-5',6'-dihydro-2'H-1',4'-oxazin-2'-onyl)>-bicyclo<2.2.1>hept-2-en-7-one 
• 140867-38-5 (1R*,4R*,5R*,5'R*)-5-<5'-(3',5'-dimethyl-5',6'-dihydro-2'H-1',4'-oxazin-2'-onyl)>-bicyclo<2.2.1>hept-2-en-7-one 
• 65479-18-7 alanine 2-oxo-propyl ester; hydrobromide 

Downstream Products

• 65479-25-6 6-Isopropyl-3,5-dimethyl-2H-1,4-oxazin-2-on 

Relevant articles and documents

A new retro-aza-ene reaction: Formal reductive amination of an α-keto acid to an α-amino acid

Two diastereomeric reductive amination reagents, 1a and 1b, were synthesized. Each reagent was condensed with ethyl pyruvate as a model α-keto acid. Flash vacuum pyrolysis of the pyruvate adducts, 10a and 10b, results in cheleotropic elimination of CO, followed by a new type of retro-aza-ene reaction. A molecule of benzene and a protected alanine derivative, 11, are produced in the retro-ene reaction. This sequence constitutes the first formal more readily than distereomer 10a, indicating that an exo transition state is preferred over an endo transition state for this particular retro-aza-ene reaction.