140926-87-0

Basic information

• Product Name: 3,4,5,7-Tetra-O-benzyl-1-deoxy-1-(dimethoxyphosphoryl)-α-D-gluco-2-heptulopyranose
• Synonyms: 3,4,5,7-Tetra-O-benzyl-1-deoxy-1-(dimethoxyphosphoryl)-α-D-gluco-2-heptulopyranose
• CAS NO: 140926-87-0
• Molecular Weight: 662.717
• Mol File: 140926-87-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3,4,5,7-Tetra-O-benzyl-1-deoxy-1-(dimethoxyphosphoryl)-α-D-gluco-2-heptulopyranose(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5,7-Tetra-O-benzyl-1-deoxy-1-(dimethoxyphosphoryl)-α-D-gluco-2-heptulopyranose(140926-87-0)
• EPA Substance Registry System: 3,4,5,7-Tetra-O-benzyl-1-deoxy-1-(dimethoxyphosphoryl)-α-D-gluco-2-heptulopyranose(140926-87-0)

Safety Data

• Hazardous Substances Data: 140926-87-0(Hazardous Substances Data)

Upstream product

• 13096-62-3 (3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one 
• 756-79-6 dimethyl methane phosphonate 
• 4291-69-4 2,3,4,6-Tetra-O-benzyl-D-glucopyranose 

Downstream Products

• 1027745-76-1 (3R,4R,5S,6S)-4,5,6-tris(benzyloxy)-3-[(benzyl)methyl]-2,2-difluorocyclohexanone 
• 1413374-91-0 C₃₅H₃₆F₂O₆ 
• 213400-35-2 (1S,2S,3S,4R)-2,3,4-tri-O-benzyl-5-(benzyloxymethyl)-cyclohex-5-ene-1,2,3,4-tetrol 
• 1413373-77-9 (1R,4R,5S,6R)-4,5,6-tris(benzyloxy)-3-(benzyloxymethyl)-1-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)cyclohex-2-enol 
• 1147490-71-8 2,3,4,6-tetra-O-benzyl-1-O-(tert-butyldimethylsilyl)-5a-carba-β-D-xylo-hex-5(5a)-enopyranose 
• 1413373-99-5 C₄₁H₅₂O₆Si 
• 1413374-02-3 C₄₁H₅₀O₆Si 
• 1413374-05-6 C₃₅H₃₆O₆ 
• 1413374-08-9 C₃₇H₃₈O₇ 
• 1413374-11-4 C₃₇H₃₈F₂O₆ 
• 1413374-34-1 C₂₂H₂₅ClF₂O₆ 
• 1413374-37-4 C₅₀H₄₈BrClF₂O₅ 
• 1413374-72-7 C₅₀H₄₉ClF₂O₅ 
• 1413374-40-9 C₃₆H₃₅F₅O₇S 

Relevant articles and documents

FAMILY OF ARYL, HETEROARYL, O-ARYL AND O-HETEROARYL CARBASUGARS

The present invention relates to a compound of the following formula (I): as well as its process of preparation, pharmaceutical and cosmetics composition comprising it and use thereof, notably as an inhibitor of the sodium-dependent glucose co-transporter, such as SGLTl, SGLT2 and SGLT3, in particular in the treatment or prevention of diabetes, and more particularly type-II diabetes, diabetes-related complications, such as arthritis of the lower extremities, cardiac infarction, renal insufficiency, neuropathy or blindness, hyperglycemia, hyperinsulinemia, obesity, hypertriglyceridemia, X syndrome and arteriosclerosis, as well as for its use as an anticancer, anti-infective, anti-viral, anti-thrombotic or anti- inflammatory drug, or for lightening, bleaching, depigmenting the skin, removing blemishes from the skin, particularly age spots and freckles, or preventing pigmentation of the skin.

Stereoselective synthesis of C-glycosylphosphonates from their ketols. Reconsideration of an abandoned route

Isosteric phosphonate analogues of glycosyl 1-phosphates have been obtained by addition of LiCH2P(O)(OMe)2 to glyconolactones followed by Et3SiH-TMSOTf reductive dehydroxylation of the resultant ketols. The compounds prepared include four β-linked pyranose derivatives (D-galacto, 2-azido-2-deoxy-D-galacto, D-gluco, D-manno) and one β-linked furanose derivative (D-manno). In the latter case the ketol was activated as its 2-acetate. In agreement with an observation in another laboratory, the dehydroxylation of a model ketol phosphonate failed with the use of Et3SiH-BF3.Et2O. Copyright (C) 2000 Elsevier Science Ltd.