140944-31-6

Basic information

• Product Name: Silperisone
• Synonyms: Silperisone
• CAS NO: 140944-31-6
• Molecular Formula: C15H24FNSi
• Molecular Weight: 265.446
• Mol File: 140944-31-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 304.2°Cat760mmHg
• Flash Point: 137.8°C
• Appearance: /
• Density: 0.987g/cm³
• Vapor Pressure: 0.000887mmHg at 25°C
• Refractive Index: 1.495
• CAS DataBase Reference: Silperisone(CAS DataBase Reference)
• NIST Chemistry Reference: Silperisone(140944-31-6)
• EPA Substance Registry System: Silperisone(140944-31-6)

Safety Data

• Hazardous Substances Data: 140944-31-6(Hazardous Substances Data)

Usage

Pharmaceutical Applications

Tolperisone is a centrally acting muscle relaxant used, for example, in the treatment of acute muscle spasms in back pain. Previous in vitro and in vivo studies in mice have demonstrated that silperisone may have the potential to reduce both central nervous system depressing and motor side effects. Phase I clinical trials were conducted with doses up to 150 mg/day. No adverse side effects were detected, and the observed plasma levels were deemed to be effective in preclinical trials. Nevertheless, chronic toxicities were observed in animal studies and the research was discontinued.

InChI:InChI=1/C15H24FNSi/c1-18(2,13-17-10-4-3-5-11-17)12-14-6-8-15(16)9-7-14/h6-9H,3-5,10-13H2,1-2H3

Relevant articles and documents

Organosilane derivatives, pharmaceutical compositions containing them and process for preparing same

A method of treating a mammalian subject for Parkinson's disease or to provide a central muscle relaxant effect, which comprises the step of administering to the mammalian subject in need of the treatment, a therapeutically effective amount of a compound of the Formula (I) STR1 wherein m is 1,2 or 3; R1 and R2 each independently stand for hydrogen, C1 to C4 straight or branched chain alkyl, C1 to C4 alkoxy, C5 to C7 cycloalkyl, or halogen; and B is a 5- or 6-membered saturated or unsaturated heterocyclic group containing a nitrogen heteroatom, the heterocyclic group being bound through its heterocyclic nitrogen atom to the remainder of the compound, and which can contain one or two additional heteroatoms selected form the group consisting of an oxygen heteroatom, a sulfur heteroatom, and one or two additional nitrogen heteroatoms, which may be as an =N--, --NH-- or --NR-- group, where R is a C1 to C5 alkyl or C1 to C5 alkycarbonyl group, the nitrogen-containing heterocyclic group is unsubstituted or substituted on one of its carbon atoms by C1 to C4 alkyl or C1 to C4 alkoxycarbonyl; or a pharmaceutically acceptable salt thereof.