1409939-01-0

Basic information

• Product Name: C₆₁H₆₇N₂₃O₁₂
• CAS NO: 1409939-01-0
• Molecular Weight: 1314.35
• Mol File: 1409939-01-0.mol

Chemical Properties

• CAS DataBase Reference: C₆₁H₆₇N₂₃O₁₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₆₁H₆₇N₂₃O₁₂(1409939-01-0)
• EPA Substance Registry System: C₆₁H₆₇N₂₃O₁₂(1409939-01-0)

Safety Data

• Hazardous Substances Data: 1409939-01-0(Hazardous Substances Data)

Relevant articles and documents

Synthesis of cyclic Py-im polyamide libraries

Cyclic Py-Im polyamides containing two GABA turn units exhibit enhanced DNA binding affinity, but extensive studies of their biological properties have been hindered due to synthetic inaccessibility. A facile modular approach toward cyclic polyamides has been developed via microwave-assisted solid-phase synthesis of hairpin amino acid oligomer intermediates followed by macrocyclization. A focused library of cyclic polyamides 1-7 targeted to the androgen response element (ARE) and the estrogen response element (ERE) were synthesized in 12-17% overall yield. The Fmoc protection strategy also allows for selective modifications on the GABA turn units that have been shown to improve cellular uptake properties. The DNA binding affinities of a library of cyclic polyamides were measured by DNA thermal denaturation assays and compared to the corresponding hairpin polyamides. Fluorescein-labeled cyclic polyamides have been synthesized and imaged via confocal microscopy in A549 and T47D cell lines. The IC50 values of compounds 1-7 and 9-11 were determined, revealing remarkably varying levels of cytotoxicity.