1409944-54-2Relevant academic research and scientific papers
Automated multistep continuous flow synthesis of 2-(1H-indol-3-yl)thiazole derivatives
Pagano, Nicholas,Heil, Marintha L.,Cosford, Nicholas D. P.
, p. 2537 - 2546 (2012/09/05)
The multistep continuous flow assembly of 2-(1H-indol-3-yl)thiazoles using a Syrris AFRICA synthesis station is reported. Sequential Hantzsch thiazole synthesis, deketalization, and Fischer indole synthesis provides rapid and efficient access to highly functionalized, pharmacologically significant 2-(1H-indol-3-yl)thiazoles. These complex drug-like small molecules are generated in reaction times of less than 15 minutes and in high yields (38-82% over three chemical steps without isolation of intermediates). Georg Thieme Verlag Stuttgart · New York.
