1409964-75-5

Basic information

• Product Name: 4-bromo-1-chloro-6-methoxyIsoquinoline
• Synonyms: 4-bromo-1-chloro-6-methoxyIsoquinoline
• CAS NO: 1409964-75-5
• Molecular Weight: 0
• Mol File: 1409964-75-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-bromo-1-chloro-6-methoxyIsoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-1-chloro-6-methoxyIsoquinoline(1409964-75-5)
• EPA Substance Registry System: 4-bromo-1-chloro-6-methoxyIsoquinoline(1409964-75-5)

Safety Data

• Hazardous Substances Data: 1409964-75-5(Hazardous Substances Data)

Upstream product

• 26829-43-6 6-methoxy-2H-isoquinolin-1-one 
• 923278-23-3 4-bromo-6-methoxyisoquinolin-1(2H)-one 
• 26829-43-6 6-methoxy-2H-isoquinolin-1-one 
• 6099-04-3 trans-3-methoxycinnamic acid 
• 872496-89-4 (E)-3-(3-methoxyphenyl)acryloyl azide 

Downstream Products

• 1781486-94-9 4-bromo-6-methoxyisoquinoline 

Relevant articles and documents

Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity

Tau prions feature in the brains of patients suffering from Alzheimer's disease and other tauopathies. For the development of therapeutics that target the replication of tau prions, a high-content, fluorescence-based cell assay was developed. Using this high-content phenotypic screen for nascent tau prion formation, a 4-piperazine isoquinoline compound (1) was identified as a hit with an EC50 value of 390 nM and 0.04 Kp,uu. Analogs were synthesized using a hypothesis-based approach to improve potency and in vivo brain penetration resulting in compound 25 (EC50 = 15 nM; Kp,uu = 0.63). We investigated the mechanism of action of this series and found that a small set of active compounds were also CDK8 inhibitors.

HEPATITIS C VIRUS INHIBITORS

Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.